| 9/4/2021 | Villanova (10-3) | 47 | at | Lehigh | 3 | CAAF | ||
| 9/11/2021 | Lehigh | 3 | at | Richmond (6-5) | 31 | at CAAF | ||
| 9/18/2021 | Princeton (9-1) | 32 | at | Lehigh | 0 | Ivy | ||
| 9/25/2021 | Lehigh | 3 | at | Colgate (5-6,5-1) | 30 | |||
| 10/2/2021 | Yale (5-5) | 34 | at | Lehigh | 0 | Ivy | ||
| 10/9/2021 | Lehigh | 0 | at | Pennsylvania (3-7) | 20 | at Ivy | ||
| 10/23/2021 | Lehigh | 28 | at | Fordham (6-5,4-2) | 35 | |||
| 10/30/2021 | Holy Cross (10-3,6-0) | 31 | at | Lehigh | 12 | |||
| 11/6/2021 | Lehigh | 38 | at | Bucknell (1-10,0-6) | 6 | |||
| 11/13/2021 | Georgetown (2-8,1-5) | 9 | at | Lehigh | 23 | |||
| 11/20/2021 | Lafayette (3-8,2-4) | 10 | at | Lehigh | 17 |
| vs Lehigh | vs Other Opponents | Lehigh compared to OOs | |
| Record: | 8-3 | 52-58 | |
| Points Scored: | 25.91 | 24.23 | -1.68 |
| Points Allowed: | 11.55 | 25.51 | -13.96 |
| Margin: | 14.36 | -1.28 | -15.64 |
| Total Points: | 37.46 | 49.74 | -12.28 |