| 9/4/2021 | Lafayette | 14 | at | Air Force (10-3) | 35 | at MW | ||
| 9/11/2021 | Lafayette | 3 | at | William & Mary (6-5) | 24 | at CAAF | ||
| 9/18/2021 | New Hampshire (3-8) | 19 | at | Lafayette | 13 | CAAF | ||
| 9/25/2021 | Pennsylvania (3-7) | 14 | at | Lafayette | 24 | Ivy | ||
| 10/2/2021 | Fordham (6-5,4-2) | 42 | at | Lafayette | 41 | |||
| 10/9/2021 | Bucknell (1-10,0-6) | 0 | at | Lafayette | 27 | |||
| 10/16/2021 | Lafayette | 3 | at | Harvard (8-2) | 30 | at Ivy | ||
| 10/30/2021 | Lafayette | 24 | at | Georgetown (2-8,1-5) | 23 | |||
| 11/6/2021 | Lafayette | 10 | at | Holy Cross (10-3,6-0) | 35 | |||
| 11/13/2021 | Colgate (5-6,5-1) | 20 | at | Lafayette | 13 | |||
| 11/20/2021 | Lafayette | 10 | at | Lehigh (3-8,3-3) | 17 |
| vs Lafayette | vs Other Opponents | Lafayette compared to OOs | |
| Record: | 8-3 | 49-62 | |
| Points Scored: | 23.55 | 22.54 | -1.01 |
| Points Allowed: | 16.55 | 26.07 | -9.52 |
| Margin: | 7.00 | -3.53 | -10.53 |
| Total Points: | 40.10 | 48.61 | -8.51 |