9/3/2021 | Salisbury | 56 | at | Albright | 14 | | | NJAC |
| Merchant Marine | 49 | at | Fairleigh Dickinson-Florham | 27 | | | NEWMAC |
| Delaware Valley | 57 | at | Kean | 6 | | | @ NJAC |
| Alvernia | 6 | at | Ursinus | 42 | | | @ Cen |
9/4/2021 | Moravian | 10 | at | King's | 13 | | | Cen |
| Franklin & Marshall | 14 | at | Lebanon Valley | 19 | | | Cen |
| Widener | 27 | at | Rowan | 22 | | | @ NJAC |
| Johns Hopkins | 53 | at | Stevenson | 18 | | | Cen |
| Lycoming | 10 | at | Susquehanna | 44 | | | @ Cen |
| Keystone | 7 | at | Wilkes | 46 | | | ECFC |
9/11/2021 | Montclair State | 2 | at | Delaware Valley | 26 | | | NJAC |
| Alvernia | 14 | at | Hartwick | 23 | | | @ E8 |
| Misericordia | 28 | at | Keystone | 7 | | | @ ECFC |
| Lebanon Valley | 6 | at | Lycoming | 31 | | | |
| Stevenson | 10 | at | Rensselaer | 14 | | | @ LL |
| Albright | 33 | at | Western Connecticut | 28 | | | @ MSCAC |
| Hampden-Sydney | 27 | at | Widener | 34 | | | ODC |
| Fairleigh Dickinson-Florham | 43 | at | William Paterson | 17 | | | @ NJAC |
9/18/2021 | Albright | 31 | at | Alvernia | 21 | | | |
| Stevenson | 17 | at | Delaware Valley | 34 | | | |
| Lycoming | 28 | at | King's | 8 | | | |
| Wilkes | 35 | at | Misericordia | 15 | | | |
| Lebanon Valley | 3 | at | Widener | 24 | | | |
9/25/2021 | Widener | 21 | at | Albright | 7 | | | |
| Misericordia | 20 | at | Fairleigh Dickinson-Florham | 31 | | | |
| King's | 6 | at | Lebanon Valley | 24 | | | |
| Lycoming | 29 | at | Stevenson | 28 | | | |
| Alvernia | 0 | at | Wilkes | 23 | | | |
10/2/2021 | Alvernia | 7 | at | King's | 10 | | | |
| Delaware Valley | 32 | at | Lycoming | 7 | | | |
| Albright | 20 | at | Misericordia | 31 | | | |
| Fairleigh Dickinson-Florham | 27 | at | Widener | 3 | | | |
| Stevenson | 14 | at | Wilkes | 21 | | | |
10/9/2021 | Wilkes | 31 | at | Albright | 28 | | | |
| Widener | 37 | at | Alvernia | 7 | | | |
| King's | 15 | at | Delaware Valley | 48 | | | |
| Fairleigh Dickinson-Florham | 33 | at | Lebanon Valley | 27 | 2OT | | |
| Misericordia | 16 | at | Lycoming | 44 | | | |
10/16/2021 | Delaware Valley | 61 | at | Fairleigh Dickinson-Florham | 7 | | | |
| Albright | 12 | at | King's | 51 | | | |
| Alvernia | 10 | at | Lebanon Valley | 31 | | | |
| Misericordia | 0 | at | Stevenson | 37 | | | |
| Wilkes | 13 | at | Widener | 30 | | | |
10/23/2021 | Fairleigh Dickinson-Florham | 20 | at | King's | 23 | | | |
| Albright | 7 | at | Lycoming | 28 | | | |
| Delaware Valley | 35 | at | Misericordia | 0 | | | |
| Widener | 24 | at | Stevenson | 29 | | | |
| Lebanon Valley | 20 | at | Wilkes | 30 | | | |
10/30/2021 | Fairleigh Dickinson-Florham | 42 | at | Albright | 35 | | | |
| Stevenson | 35 | at | Alvernia | 6 | | | |
| Lebanon Valley | 3 | at | Delaware Valley | 31 | | | |
| Wilkes | 27 | at | Lycoming | 30 | | | |
| King's | 17 | at | Misericordia | 24 | | | |
11/6/2021 | Alvernia | 14 | at | Fairleigh Dickinson-Florham | 34 | | | |
| Misericordia | 17 | at | Lebanon Valley | 31 | | | |
| King's | 10 | at | Stevenson | 35 | | | |
| Lycoming | 0 | at | Widener | 17 | | | |
| Delaware Valley | 30 | at | Wilkes | 0 | | | |
11/13/2021 | Lebanon Valley | 25 | at | Albright | 2 | | | |
| Lycoming | 48 | at | Alvernia | 0 | | | |
| Widener | 0 | at | Delaware Valley | 27 | | | |
| Stevenson | 52 | at | Fairleigh Dickinson-Florham | 33 | | | |
| Wilkes | 7 | at | King's | 34 | | | |
11/20/2021 | Anna Maria | 10 | at | Delaware Valley | 62 | | | ECFC |
| St Vincent | 19 | at | Fairleigh Dickinson-Florham | 38 | | | TPAC |
| Stevenson | 28 | at | Franklin & Marshall | 42 | | | @ Cen |
| Ursinus | 23 | at | Lycoming | 31 | | | Cen |
| Widener | 21 | at | Susquehanna | 49 | | | @ Cen |
11/27/2021 | Muhlenberg | 14 | at | Delaware Valley | 0 | | | Cen |