| 9/4/2021 | Franklin & Marshall | 14 | at | Lebanon Valley (5-5) | 19 | at MidAC | ||
| 9/11/2021 | Susquehanna (9-2,7-2) | 30 | at | Franklin & Marshall | 28 | 5OT | ||
| 9/18/2021 | McDaniel (2-8,2-7) | 0 | at | Franklin & Marshall | 35 | |||
| 9/25/2021 | Franklin & Marshall | 0 | at | Ursinus (7-4,6-3) | 28 | |||
| 10/2/2021 | Franklin & Marshall | 10 | at | Johns Hopkins (10-2,8-1) | 66 | |||
| 10/16/2021 | Juniata (1-9,1-8) | 13 | at | Franklin & Marshall | 41 | |||
| 10/23/2021 | Franklin & Marshall | 17 | at | Dickinson (4-6,4-5) | 13 | |||
| 10/30/2021 | Muhlenberg (11-2,8-1) | 27 | at | Franklin & Marshall | 10 | |||
| 11/6/2021 | Franklin & Marshall | 14 | at | Moravian (3-7,3-6) | 10 | |||
| 11/13/2021 | Gettysburg (1-9,1-8) | 14 | at | Franklin & Marshall | 42 | |||
| 11/20/2021 | Stevenson (5-6) | 28 | at | Franklin & Marshall | 42 | MidAC |
| vs Franklin & Marshall | vs Other Opponents | Franklin & Marshall compared to OOs | |
| Record: | 5-6 | 53-54 | |
| Points Scored: | 22.55 | 26.16 | 3.61 |
| Points Allowed: | 23.00 | 24.51 | -1.51 |
| Margin: | -0.45 | 1.65 | 2.10 |
| Total Points: | 45.55 | 50.67 | -5.12 |