| 9/3/2021 | Alvernia (0-10) | 6 | at | Ursinus | 42 | MidAC | ||
| 9/11/2021 | Ursinus | 21 | at | Johns Hopkins (10-2,8-1) | 49 | |||
| 9/18/2021 | Ursinus | 42 | at | Muhlenberg (11-2,8-1) | 35 | |||
| 9/25/2021 | Franklin & Marshall (6-5,5-4) | 0 | at | Ursinus | 28 | |||
| 10/2/2021 | Susquehanna (9-2,7-2) | 62 | at | Ursinus | 23 | |||
| 10/16/2021 | Ursinus | 18 | at | McDaniel (2-8,2-7) | 14 | |||
| 10/23/2021 | Ursinus | 34 | at | Moravian (3-7,3-6) | 7 | |||
| 10/30/2021 | Gettysburg (1-9,1-8) | 21 | at | Ursinus | 42 | |||
| 11/6/2021 | Juniata (1-9,1-8) | 7 | at | Ursinus | 44 | |||
| 11/13/2021 | Ursinus | 20 | at | Dickinson (4-6,4-5) | 27 | OT | ||
| 11/20/2021 | Ursinus | 23 | at | Lycoming (8-3) | 31 | at MidAC |
| vs Ursinus | vs Other Opponents | Ursinus compared to OOs | |
| Record: | 4-7 | 51-56 | |
| Points Scored: | 23.55 | 24.14 | 0.59 |
| Points Allowed: | 30.64 | 24.17 | 6.47 |
| Margin: | -7.09 | -0.03 | 7.06 |
| Total Points: | 54.19 | 48.31 | 5.88 |