| 9/4/2021 | New Jersey (3-6) | 0 | at | Muhlenberg | 41 | NJAC | ||
| 9/11/2021 | Muhlenberg | 34 | at | Dickinson (4-6,4-5) | 13 | |||
| 9/18/2021 | Ursinus (7-4,6-3) | 42 | at | Muhlenberg | 35 | |||
| 9/25/2021 | Muhlenberg | 23 | at | McDaniel (2-8,2-7) | 0 | |||
| 10/2/2021 | Muhlenberg | 54 | at | Gettysburg (1-9,1-8) | 19 | |||
| 10/15/2021 | Johns Hopkins (10-2,8-1) | 6 | at | Muhlenberg | 21 | |||
| 10/23/2021 | Juniata (1-9,1-8) | 16 | at | Muhlenberg | 56 | |||
| 10/30/2021 | Muhlenberg | 27 | at | Franklin & Marshall (6-5,5-4) | 10 | |||
| 11/6/2021 | Muhlenberg | 52 | at | Susquehanna (9-2,7-2) | 27 | |||
| 11/13/2021 | Moravian (3-7,3-6) | 0 | at | Muhlenberg | 55 | |||
| 11/20/2021 | Framingham State (8-3) | 0 | at | Muhlenberg | 45 | MSCAC | ||
| 11/27/2021 | Muhlenberg | 14 | at | Delaware Valley (11-1) | 0 | at MidAC | ||
| 12/4/2021 | Muhlenberg | 29 | at | Mount Union (13-1) | 35 | OT | at OAC |
| vs Muhlenberg | vs Other Opponents | Muhlenberg compared to OOs | |
| Record: | 2-11 | 76-52 | |
| Points Scored: | 12.92 | 28.66 | 15.74 |
| Points Allowed: | 37.38 | 21.13 | 16.25 |
| Margin: | -24.46 | 7.53 | 31.99 |
| Total Points: | 50.30 | 49.79 | 0.51 |