| 9/4/2021 | Keystone | 7 | at | Wilkes (6-4) | 46 | at MidAC | ||
| 9/11/2021 | Misericordia (3-6) | 28 | at | Keystone | 7 | MidAC | ||
| 9/18/2021 | William Paterson (4-6) | 42 | at | Keystone | 14 | NJAC | ||
| 9/25/2021 | Keystone | 14 | at | Hobart (9-2) | 58 | at LL | ||
| 10/2/2021 | Anna Maria (7-3,5-1) | 55 | at | Keystone | 35 | |||
| 10/9/2021 | Keystone | 14 | at | Gallaudet (4-3,3-3) | 34 | |||
| 10/16/2021 | Dean (2-8,1-5) | 39 | at | Keystone | 36 | |||
| 10/23/2021 | Keystone | 0 | at | Castleton State (6-4,4-2) | 41 | |||
| 10/30/2021 | Alfred State (6-5,5-1) | 38 | at | Keystone | 7 | |||
| 11/6/2021 | Keystone | 21 | at | SUNY-Maritime (3-6,3-3) | 24 |
| vs Keystone | vs Other Opponents | Keystone compared to OOs | |
| Record: | 10-0 | 40-47 | |
| Points Scored: | 40.50 | 22.91 | -17.59 |
| Points Allowed: | 15.50 | 25.39 | -9.89 |
| Margin: | 25.00 | -2.48 | -27.48 |
| Total Points: | 56.00 | 48.30 | 7.70 |