| 9/11/2021 | Alvernia (0-10) | 14 | at | Hartwick | 23 | MidAC | ||
| 9/18/2021 | Hartwick | 7 | at | Curry (3-6) | 14 | at CCF | ||
| 10/2/2021 | Utica (6-5,3-3) | 16 | at | Hartwick | 10 | |||
| 10/9/2021 | Hartwick | 21 | at | Alfred (5-5,4-2) | 24 | |||
| 10/16/2021 | Cortland (11-1,7-0) | 48 | at | Hartwick | 3 | |||
| 10/23/2021 | Hartwick | 14 | at | Brockport State (8-3,5-2) | 41 | |||
| 10/30/2021 | St John Fisher (4-6,3-4) | 28 | at | Hartwick | 7 | |||
| 11/6/2021 | Rochester (3-7) | 42 | at | Hartwick | 28 | LL | ||
| 11/13/2021 | Morrisville (2-8,2-5) | 7 | at | Hartwick | 14 |
| vs Hartwick | vs Other Opponents | Hartwick compared to OOs | |
| Record: | 7-2 | 35-49 | |
| Points Scored: | 26.00 | 19.79 | -6.21 |
| Points Allowed: | 14.11 | 24.94 | -10.83 |
| Margin: | 11.89 | -5.15 | -17.04 |
| Total Points: | 40.11 | 44.73 | -4.62 |