| 9/3/2021 | Salisbury | 56 | at | Albright (2-8) | 14 | at MidAC | ||
| 9/11/2021 | Wisconsin-Whitewater (13-1) | 31 | at | Salisbury | 14 | WIAC | ||
| 9/25/2021 | Western New England (7-4) | 14 | at | Salisbury | 40 | CCF | ||
| 10/2/2021 | Salisbury | 27 | at | Montclair State (3-7,2-4) | 7 | |||
| 10/16/2021 | Salisbury | 24 | at | Rowan (2-7,2-4) | 7 | |||
| 10/23/2021 | Kean (4-5,4-2) | 6 | at | Salisbury | 38 | |||
| 10/30/2021 | Salisbury | 84 | at | Christopher Newport (5-5,3-3) | 14 | |||
| 11/6/2021 | New Jersey (3-6,2-4) | 23 | at | Salisbury | 37 | |||
| 11/13/2021 | William Paterson (4-6,2-4) | 7 | at | Salisbury | 38 | |||
| 11/20/2021 | Johns Hopkins (10-2) | 45 | at | Salisbury | 20 | Cen |
| vs Salisbury | vs Other Opponents | Salisbury compared to OOs | |
| Record: | 2-8 | 51-43 | |
| Points Scored: | 16.80 | 27.31 | 10.51 |
| Points Allowed: | 37.80 | 21.22 | 16.58 |
| Margin: | -21.00 | 6.09 | 27.09 |
| Total Points: | 54.60 | 48.53 | 6.07 |