| 9/11/2021 | Nichols (2-8) | 27 | at | Anna Maria | 23 | CCF | ||
| 9/18/2021 | Massachusetts Maritime (4-6) | 13 | at | Anna Maria | 23 | MSCAC | ||
| 9/25/2021 | Anna Maria | 29 | at | Coast Guard (2-8) | 24 | at NEWMAC | ||
| 10/2/2021 | Anna Maria | 55 | at | Keystone (0-10,0-6) | 35 | |||
| 10/16/2021 | Anna Maria | 28 | at | Alfred State (6-5,5-1) | 17 | |||
| 10/23/2021 | Dean (2-8,1-5) | 32 | at | Anna Maria | 45 | |||
| 10/30/2021 | Anna Maria | 31 | at | Castleton State (6-4,4-2) | 38 | |||
| 11/6/2021 | Gallaudet (4-3,3-3) | 21 | at | Anna Maria | 37 | |||
| 11/13/2021 | SUNY-Maritime (3-6,3-3) | 7 | at | Anna Maria | 31 | |||
| 11/20/2021 | Anna Maria | 10 | at | Delaware Valley (11-1) | 62 | at MidAC |
| vs Anna Maria | vs Other Opponents | Anna Maria compared to OOs | |
| Record: | 3-7 | 37-52 | |
| Points Scored: | 27.60 | 21.09 | -6.51 |
| Points Allowed: | 31.20 | 24.64 | 6.56 |
| Margin: | -3.60 | -3.55 | 0.05 |
| Total Points: | 58.80 | 45.73 | 13.07 |