| 9/3/2020 | South Alabama | 32 | at | Southern Miss | 21 | SBC | ||
| Central Arkansas | 35 | at | UAB | 45 | SLC (1AA) | |||
| 9/5/2020 | Middle Tenn State | 0 | at | Army | 42 | @ Ind | ||
| Eastern Kentucky | 0 | at | Marshall | 59 | OVC (1AA) | |||
| Houston Baptist | 31 | at | North Texas | 57 | SLC (1AA) | |||
| Stephen F. Austin | 14 | at | UTEP | 24 | SLC (1AA) | |||
| 9/10/2020 | UAB | 14 | at | Miami-Florida | 31 | @ ACC | ||
| 9/12/2020 | UNC-Charlotte | 20 | at | Appalachian State | 35 | @ SBC | ||
| Western Kentucky | 21 | at | Louisville | 35 | @ ACC | |||
| UTEP | 3 | at | Texas | 59 | @ B12 | |||
| Texas-San Antonio | 51 | at | Texas State | 48 | @ SBC | |||
| 9/19/2020 | Appalachian State | 7 | at | Marshall | 17 | SBC | ||
| Troy | 47 | at | Middle Tenn State | 14 | SBC | |||
| SMU | 65 | at | North Texas | 35 | AAC | |||
| Louisiana Tech | 31 | at | Southern Miss | 30 | ||||
| Stephen F. Austin | 10 | at | Texas-San Antonio | 24 | SLC (1AA) | |||
| Abilene Christian | 13 | at | UTEP | 17 | SLC (1AA) | |||
| Liberty | 30 | at | Western Kentucky | 24 | Ind | |||
| 9/24/2020 | UAB | 42 | at | South Alabama | 10 | @ SBC | ||
| 9/25/2020 | Middle Tenn State | 35 | at | Texas-San Antonio | 37 | |||
| 9/26/2020 | Florida Intl | 34 | at | Liberty | 36 | @ Ind | ||
| Houston Baptist | 38 | at | Louisiana Tech | 66 | SLC (1AA) | |||
| Tulane | 66 | at | Southern Miss | 24 | AAC | |||
| UTEP | 31 | at | UL Monroe | 6 | @ SBC | |||
| 10/2/2020 | Louisiana Tech | 14 | at | BYU | 45 | @ Ind | ||
| 10/3/2020 | UNC-Charlotte | 17 | at | Florida Atlantic | 21 | |||
| Western Kentucky | 20 | at | Middle Tenn State | 17 | ||||
| Southern Miss | 41 | at | North Texas | 31 | ||||
| Texas-San Antonio | 13 | at | UAB | 21 | ||||
| 10/10/2020 | Texas-San Antonio | 20 | at | BYU | 27 | @ Ind | ||
| Middle Tenn State | 31 | at | Florida Intl | 28 | ||||
| UTEP | 17 | at | Louisiana Tech | 21 | ||||
| UNC-Charlotte | 49 | at | North Texas | 21 | ||||
| Marshall | 38 | at | Western Kentucky | 14 | ||||
| 10/17/2020 | Florida Intl | at | UNC-Charlotte | PPD | ||||
| Marshall | 35 | at | Louisiana Tech | 17 | ||||
| North Texas | 52 | at | Middle Tenn State | 35 | ||||
| Western Kentucky | 14 | at | UAB | 37 | ||||
| Army | 28 | at | Texas-San Antonio | 16 | Ind | |||
| Southern Miss | at | UTEP | PPD | |||||
| 10/23/2020 | Jacksonville State | 19 | at | Florida Intl | 10 | OVC (1AA) | ||
| UL Lafayette | 24 | at | UAB | 20 | SBC | |||
| 10/24/2020 | UTEP | 28 | at | UNC-Charlotte | 38 | |||
| Jacksonville State | 19 | at | Florida Intl | 10 | OVC (1AA) | |||
| Southern Miss | 35 | at | Liberty | 56 | @ Ind | |||
| Florida Atlantic | 9 | at | Marshall | 20 | ||||
| Middle Tenn State | 40 | at | Rice | 34 | OT | |||
| Louisiana Tech | 26 | at | Texas-San Antonio | 27 | ||||
| Chattanooga | 10 | at | Western Kentucky | 13 | SoCon (1AA) | |||
| 10/30/2020 | Marshall | at | Florida Intl | PPD | ||||
| 10/31/2020 | Western Kentucky | 10 | at | BYU | 41 | @ Ind | ||
| UNC-Charlotte | 19 | at | Duke | 53 | @ ACC | |||
| Texas-San Antonio | 3 | at | Florida Atlantic | 24 | ||||
| UAB | 34 | at | Louisiana Tech | 37 | 2OT | |||
| Rice | 30 | at | Southern Miss | 6 | ||||
| North Texas | at | UTEP | PPD | |||||
| 11/7/2020 | Western Kentucky | 6 | at | Florida Atlantic | 10 | |||
| Massachusetts | 10 | at | Marshall | 51 | Ind | |||
| UNC-Charlotte | at | Middle Tenn State | PPD | |||||
| Louisiana Tech | at | North Texas | PPD | |||||
| Texas-San Antonio | at | Rice | PPD | |||||
| North Alabama | 13 | at | Southern Miss | 24 | BigS (1AA) | |||
| Florida Intl | at | UTEP | CCD | |||||
| 11/13/2020 | Florida Atlantic | 38 | at | Florida Intl | 19 | |||
| 11/14/2020 | Gardner-Webb | at | UNC-Charlotte | CCD | BigS (1AA) | |||
| Rice | at | Louisiana Tech | PPD | |||||
| Middle Tenn State | at | Marshall | ||||||
| North Texas | at | UAB | CCD | |||||
| UTEP | 21 | at | Texas-San Antonio | 52 | ||||
| Southern Miss | 7 | at | Western Kentucky | 10 | ||||
| 11/20/2020 | Massachusetts | 2 | at | Florida Atlantic | 24 | Ind | ||
| UAB | at | UTEP | CCD | |||||
| 11/21/2020 | UL Monroe | at | Louisiana Tech | CCD Shreveport, LA | SBC | |||
| UNC-Charlotte | at | Marshall | PPD | |||||
| Rice | 17 | at | North Texas | 27 | ||||
| Texas-San Antonio | 23 | at | Southern Miss | 20 | ||||
| Middle Tenn State | 20 | at | Troy | 17 | @ SBC | |||
| Florida Intl | 21 | at | Western Kentucky | 38 | ||||
| 11/27/2020 | Southern Miss | at | UAB | CCD | ||||
| 11/28/2020 | Louisiana Tech | at | Florida Intl | CCD | ||||
| Florida Atlantic | at | Middle Tenn State | PPD | |||||
| UTEP | at | Rice | CCD | |||||
| North Texas | 17 | at | Texas-San Antonio | 49 | ||||
| 12/3/2020 | Louisiana Tech | 42 | at | North Texas | 31 | |||
| 12/4/2020 | Southern Miss | at | UTEP | CCD | ||||
| 12/5/2020 | Florida Atlantic | 3 | at | Georgia Southern | 20 | @ SBC | ||
| Rice | 20 | at | Marshall | 0 | ||||
| 12/6/2020 | Western Kentucky | 37 | at | UNC-Charlotte | 19 | |||
| 12/10/2020 | Florida Atlantic | 31 | at | Southern Miss | 45 | |||
| 12/11/2020 | UNC-Charlotte | at | Marshall | CCD | ||||
| North Texas | 45 | at | UTEP | 43 | ||||
| 12/12/2020 | UAB | 21 | at | Rice | 16 | |||
| Louisiana Tech | 10 | at | TCU | 52 | @ B12 | |||
| 12/18/2020 | UAB | 22 | at | Marshall | 13 | CUSA Championship | ||
| 12/19/2020 | SMU | at | Texas-San Antonio | CCD | AAC | |||
| 12/21/2020 | Appalachian State | 56 | vs | North Texas | 28 | Myrtle Beach Bowl | vs SBC | |
| 12/23/2020 | Memphis | 25 | vs | Florida Atlantic | 10 | Montgomer Bowl | vs AAC | |
| Louisiana Tech | 3 | vs | Georgia Southern | 38 | New Orleans Bowl | vs SBC | ||
| 12/25/2020 | Marshall | 10 | vs | Buffalo | 17 | Camelia Bowl | vs MAC | |
| 12/26/2020 | Western Kentucky | 21 | vs | Georgia State | 39 | Lending Tree Bowl | vs SBC | |
| South Carolina | vs | UAB | CCD Gasparilla Bowl | vs SEC | ||||
| UL Lafayette | 31 | vs | Texas-San Antonio | 24 | First Responder Bowl | vs SBC |