| 9/12/2020 | Western Kentucky (5-7) | 21 | at | Louisville | 35 | CUSA | ||
| 9/19/2020 | Miami-Florida (8-3,7-2) | 47 | at | Louisville | 34 | |||
| 9/26/2020 | Louisville | 20 | at | Pittsburgh (6-5,5-5) | 23 | |||
| 10/9/2020 | Louisville | 27 | at | Georgia Tech (3-7,3-6) | 46 | |||
| 10/17/2020 | Louisville | 7 | at | Notre Dame (10-2,9-1) | 12 | |||
| 10/24/2020 | Florida State (3-6,2-6) | 16 | at | Louisville | 48 | |||
| 10/31/2020 | Virginia Tech (5-6,5-5) | 42 | at | Louisville | 35 | |||
| 11/7/2020 | Louisville | at | Virginia (5-5,4-5) | PPD | ||||
| 11/14/2020 | Louisville | 17 | aT | Virginia (5-5,4-5) | 31 | |||
| 11/20/2020 | Syracuse (1-10,1-9) | 0 | at | Louisville | 30 | |||
| 11/28/2020 | Louisville | 27 | at | Boston College (6-5,5-5) | 34 | |||
| 12/12/2020 | Wake Forest (4-5,3-4) | 21 | at | Louisville | 45 |
| vs Louisville | vs Other Opponents | Louisville compared to OOs | |
| Record: | 7-4 | 53-62 | |
| Points Scored: | 26.64 | 28.54 | 1.90 |
| Points Allowed: | 29.55 | 29.44 | 0.11 |
| Margin: | -2.91 | -0.90 | 2.01 |
| Total Points: | 56.19 | 57.98 | -1.79 |