| 9/12/2020 | Duke | 13 | at | Notre Dame (10-2,9-1) | 27 | |||
| 9/19/2020 | Boston College (6-5,5-5) | 26 | at | Duke | 6 | |||
| 9/26/2020 | Duke | 20 | at | Virginia (5-5,4-5) | 38 | |||
| 10/3/2020 | Virginia Tech (5-6,5-5) | 38 | at | Duke | 31 | |||
| 10/10/2020 | Duke | 38 | at | Syracuse (1-10,1-9) | 24 | |||
| 10/17/2020 | Duke | 20 | at | North Carolina State (8-4,7-3) | 31 | |||
| 10/31/2020 | UNC-Charlotte (2-4) | 19 | at | Duke | 53 | CUSA | ||
| 11/7/2020 | North Carolina (8-4,7-3) | 56 | at | Duke | 24 | |||
| 11/21/2020 | Wake Forest (4-5,3-4) | at | Duke | CCD | ||||
| 11/28/2020 | Duke | 33 | at | Georgia Tech (3-7,3-6) | 56 | |||
| 12/5/2020 | Miami-Florida (8-3,7-2) | 48 | at | Duke | 0 | |||
| 12/12/2020 | Duke | 35 | at | Florida State (3-6,2-6) | 56 |
| vs Duke | vs Other Opponents | Duke compared to OOs | |
| Record: | 9-2 | 54-59 | |
| Points Scored: | 38.09 | 29.44 | -8.65 |
| Points Allowed: | 24.82 | 30.67 | -5.85 |
| Margin: | 13.27 | -1.23 | -14.50 |
| Total Points: | 62.91 | 60.11 | 2.80 |