| 9/12/2020 | Campbell (0-4) | 26 | at | Georgia Southern | 27 | BigS (1AA) | ||
| 9/26/2020 | Georgia Southern | 18 | at | UL Lafayette (10-1,7-1) | 20 | |||
| 10/3/2020 | Georgia Southern | 35 | at | UL Monroe (0-10,0-7) | 30 | |||
| 10/17/2020 | Massachusetts (0-4) | 0 | at | Georgia Southern | 41 | Ind | ||
| 10/24/2020 | Georgia Southern | 14 | at | Coastal Carolina (11-1,8-0) | 28 | |||
| 10/29/2020 | South Alabama (4-7,3-5) | 17 | at | Georgia Southern | 24 | |||
| 11/7/2020 | Troy (5-6,3-4) | 13 | at | Georgia Southern | 20 | |||
| 11/14/2020 | Texas State (2-10,2-6) | 38 | at | Georgia Southern | 40 | |||
| 11/21/2020 | Georgia Southern | 27 | at | Army (9-3) | 28 | at Ind | ||
| 11/28/2020 | Georgia Southern | 24 | at | Georgia State (6-4,4-4) | 30 | |||
| 12/5/2020 | Florida Atlantic (5-4) | 3 | at | Georgia Southern | 20 | CUSA | ||
| 12/12/2020 | Appalachian State (9-3,6-2) | 34 | at | Georgia Southern | 26 | |||
| 12/23/2020 | Louisiana Tech (5-5) | 3 | vs | Georgia Southern | 38 | New Orleans Bowl | CUSA |
| vs Georgia Southern | vs Other Opponents | Georgia Southern compared to OOs | |
| Record: | 5-8 | 61-54 | |
| Points Scored: | 20.77 | 27.41 | 6.64 |
| Points Allowed: | 27.23 | 27.65 | -0.42 |
| Margin: | -6.46 | -0.24 | 6.22 |
| Total Points: | 48.00 | 55.06 | -7.06 |