| 9/12/2020 | UNC-Charlotte (2-4) | 20 | at | Appalachian State | 35 | CUSA | ||
| 9/19/2020 | Appalachian State | 7 | at | Marshall (6-3) | 17 | at CUSA | ||
| 9/26/2020 | Campbell (0-4) | 21 | at | Appalachian State | 52 | BigS (1AA) | ||
| 10/22/2020 | Arkansas State (4-7,2-6) | 17 | at | Appalachian State | 45 | |||
| 10/31/2020 | Appalachian State | 31 | at | UL Monroe (0-10,0-7) | 13 | |||
| 11/7/2020 | Appalachian State | 38 | at | Texas State (2-10,2-6) | 17 | |||
| 11/14/2020 | Georgia State (6-4,4-4) | 13 | at | Appalachian State | 17 | |||
| 11/21/2020 | Appalachian State | 23 | at | Coastal Carolina (11-1,8-0) | 34 | |||
| 11/28/2020 | Troy (5-6,3-4) | 10 | at | Appalachian State | 47 | |||
| 12/4/2020 | UL Lafayette (10-1,7-1) | 24 | at | Appalachian State | 21 | |||
| 12/12/2020 | Appalachian State | 34 | at | Georgia Southern (8-5,4-4) | 26 | |||
| 12/21/2020 | Appalachian State | 56 | vs | North Texas (4-6) | 28 | Myrtle Beach Bowl | vs CUSA |
| vs Appalachian State | vs Other Opponents | Appalachian State compared to OOs | |
| Record: | 3-9 | 55-52 | |
| Points Scored: | 20.00 | 30.39 | 10.39 |
| Points Allowed: | 33.83 | 29.56 | 4.27 |
| Margin: | -13.83 | 0.83 | 14.66 |
| Total Points: | 53.83 | 59.95 | -6.12 |