| 11/4/2020 | Buffalo | 49 | at | Northern Illinois (1-5,1-5) | 30 | |||
| 11/10/2020 | Miami-Ohio (2-1,2-1) | 10 | at | Buffalo | 42 | |||
| 11/17/2020 | Buffalo | 42 | at | Bowling Green (0-5,0-5) | 17 | |||
| 11/28/2020 | Kent State (3-1,3-1) | 41 | at | Buffalo | 70 | |||
| 12/5/2020 | Buffalo | at | Ohio (2-1,2-1) | CCD | ||||
| 12/12/2020 | Akron (1-5,1-5) | 7 | at | Buffalo | 56 | |||
| 12/18/2020 | Ball State (7-1,6-1) | 38 | vs | Buffalo | 28 | MAC Championship | ||
| 12/25/2020 | Marshall (6-3) | 10 | vs | Buffalo | 17 | Camelia Bowl | CUSA |
| vs Buffalo | vs Other Opponents | Buffalo compared to OOs | |
| Record: | 1-6 | 21-16 | |
| Points Scored: | 21.86 | 28.76 | 6.90 |
| Points Allowed: | 43.43 | 27.08 | 16.35 |
| Margin: | -21.57 | 1.68 | 23.25 |
| Total Points: | 65.29 | 55.84 | 9.45 |