| 9/5/2020 | SMU | 31 | at | Texas State (2-10) | 24 | at SBC | ||
| 9/19/2020 | SMU | 65 | at | North Texas (4-6) | 35 | at CUSA | ||
| 9/26/2020 | Stephen F. Austin (6-4) | 7 | at | SMU | 50 | SLC (1AA) | ||
| 10/3/2020 | Memphis (8-3,5-3) | 27 | at | SMU | 30 | |||
| 10/16/2020 | SMU | 37 | at | Tulane (6-6,3-5) | 34 | OT | ||
| 10/24/2020 | Cincinnati (9-1,7-0) | 42 | at | SMU | 13 | |||
| 10/31/2020 | Navy (3-7,3-4) | 37 | at | SMU | 51 | |||
| 11/7/2020 | SMU | 47 | at | Temple (1-6,1-6) | 23 | |||
| 11/14/2020 | SMU | 24 | at | Tulsa (6-3,6-1) | 28 | |||
| 11/21/2020 | Houston (3-5,3-3) | at | SMU | PPD | ||||
| 11/28/2020 | SMU | 38 | at | East Carolina (3-6,3-5) | 52 | |||
| 12/5/2020 | Houston (3-5,3-3) | at | SMU | PPD | ||||
| 12/19/2020 | SMU | at | Texas-San Antonio (7-5) | CCD | at CUSA |
| vs SMU | vs Other Opponents | SMU compared to OOs | |
| Record: | 3-7 | 58-60 | |
| Points Scored: | 30.90 | 28.97 | -1.93 |
| Points Allowed: | 38.60 | 29.25 | 9.35 |
| Margin: | -7.70 | -0.28 | 7.42 |
| Total Points: | 69.50 | 58.22 | 11.28 |