| 8/29/2019 | Kent State | 7 | at | Arizona State | 30 | | | @ P12 |
| Morgan State | 3 | at | Bowling Green | 46 | | | MEAC (1AA) |
| Robert Morris | 10 | at | Buffalo | 38 | | | NE (1AA) |
| Albany NY | 21 | at | Central Michigan | 38 | | | CAAF (1AA) |
| 8/31/2019 | Eastern Michigan | 30 | at | Coastal Carolina | 23 | | | @ SBC |
| Akron | 3 | at | Illinois | 42 | | | @ B10 |
| Ball State | 24 | vs | Indiana | 34 | | Indianapolis IN | vs B10 |
| Miami-Ohio | 14 | at | Iowa | 38 | | | @ B10 |
| Toledo | 24 | at | Kentucky | 38 | | | @ SEC |
| Illinois State | 10 | at | Northern Illinois | 24 | | | MVC (1AA) |
| Rhode Island | 20 | at | Ohio | 41 | | | CAAF (1AA) |
| Monmouth NJ | 13 | at | Western Michigan | 48 | | | BigS (1AA) |
| 9/7/2019 | UAB | 31 | at | Akron | 20 | | | CUSA |
| Fordham | 29 | at | Ball State | 57 | | | Pat (1AA) |
| Bowling Green | 0 | at | Kansas State | 52 | | | @ B12 |
| Kennesaw St | 23 | at | Kent State | 26 | OT | | BigS (1AA) |
| Eastern Michigan | 17 | at | Kentucky | 38 | | | @ SEC |
| Tennessee Tech | 17 | at | Miami-Ohio | 48 | | | OVC (1AA) |
| Western Michigan | 17 | at | Michigan State | 51 | | | @ B10 |
| Buffalo | 13 | at | Penn State | 45 | | | @ B10 |
| Ohio | 10 | at | Pittsburgh | 20 | | | @ ACC |
| Northern Illinois | 17 | at | Utah | 35 | | | @ P12 |
| Central Michigan | 0 | at | Wisconsin | 61 | | | @ B10 |
| 9/14/2019 | Kent State | 16 | at | Auburn | 55 | | | @ SEC |
| Florida Atlantic | 41 | at | Ball State | 31 | | | CUSA |
| Louisiana Tech | 35 | at | Bowling Green | 7 | | | CUSA |
| Akron | 24 | at | Central Michigan | 45 | | | |
| Miami-Ohio | 13 | at | Cincinnati | 35 | | | @ AAC |
| Eastern Michigan | 34 | at | Illinois | 31 | | | @ B10 |
| Buffalo | 17 | at | Liberty | 35 | | | @ Ind |
| Ohio | 31 | at | Marshall | 33 | | | @ CUSA |
| Northern Illinois | 8 | at | Nebraska | 44 | | | @ B10 |
| Murray State | 0 | at | Toledo | 45 | | | OVC (1AA) |
| Georgia State | 10 | at | Western Michigan | 57 | | | SBC |
| 9/21/2019 | Troy | 35 | at | Akron | 7 | | | SBC |
| Temple | 22 | at | Buffalo | 38 | | | AAC |
| Toledo | 41 | at | Colorado State | 35 | | | @ MW |
| Central Conn | 29 | at | Eastern Michigan | 34 | | | NE (1AA) |
| Bowling Green | 20 | at | Kent State | 62 | | | |
| Central Michigan | 12 | at | Miami-Florida | 17 | | | @ ACC |
| Ball State | 23 | at | North Carolina State | 34 | | | @ ACC |
| Miami-Ohio | 5 | at | Ohio State | 76 | | | @ B10 |
| UL Lafayette | 45 | at | Ohio | 25 | | | SBC |
| Western Michigan | 33 | at | Syracuse | 52 | | | @ ACC |
| 9/28/2019 | Akron | 29 | at | Massachusetts | 37 | | | @ Ind |
| Buffalo | 20 | at | Miami-Ohio | 34 | | | |
| BYU | 21 | at | Toledo | 28 | | | Ind |
| Northern Illinois | 18 | at | Vanderbilt | 24 | | | @ SEC |
| Central Michigan | 15 | at | Western Michigan | 31 | | | |
| 10/5/2019 | Ohio | 21 | at | Buffalo | 20 | OT | | |
| Eastern Michigan | 16 | at | Central Michigan | 42 | | | |
| Ball State | 27 | at | Northern Illinois | 20 | | | |
| Bowling Green | 0 | at | Notre Dame | 52 | | | @ ND |
| Western Michigan | 24 | at | Toledo | 31 | | | |
| Kent State | 0 | at | Wisconsin | 48 | | | @ B10 |
| 10/12/2019 | Kent State | 26 | at | Akron | 3 | | | |
| Toledo | 7 | at | Bowling Green | 20 | | | |
| New Mexico State | 28 | at | Central Michigan | 42 | | | Ind |
| Ball State | 29 | at | Eastern Michigan | 23 | | | |
| Northern Illinois | 39 | at | Ohio | 36 | | | |
| Miami-Ohio | 16 | at | Western Michigan | 38 | | | |
| 10/19/2019 | Buffalo | 21 | at | Akron | 0 | | | |
| Toledo | 14 | at | Ball State | 52 | | | |
| Central Michigan | 38 | at | Bowling Green | 20 | | | |
| Western Michigan | 27 | at | Eastern Michigan | 34 | | | |
| Northern Illinois | 24 | at | Miami-Ohio | 27 | | | |
| Kent State | 38 | at | Ohio | 45 | | | |
| 10/26/2019 | Ohio | 34 | at | Ball State | 21 | | | |
| Central Michigan | 20 | at | Buffalo | 43 | | | |
| Miami-Ohio | 23 | at | Kent State | 16 | | | |
| Akron | 0 | at | Northern Illinois | 49 | | | |
| Eastern Michigan | 34 | at | Toledo | 37 | | | |
| Bowling Green | 10 | at | Western Michigan | 49 | | | |
| 11/2/2019 | Akron | 6 | at | Bowling Green | 35 | | | |
| Northern Illinois | 10 | at | Central Michigan | 48 | | | |
| Buffalo | 43 | at | Eastern Michigan | 14 | | | |
| 11/5/2019 | Kent State | 33 | at | Toledo | 35 | | | |
| Ball State | 31 | at | Western Michigan | 35 | | | |
| 11/6/2019 | Miami-Ohio | 24 | at | Ohio | 21 | | | |
| 11/12/2019 | Eastern Michigan | 42 | at | Akron | 14 | | | |
| Western Michigan | 37 | at | Ohio | 34 | OT | | |
| 11/13/2019 | Bowling Green | 3 | at | Miami-Ohio | 44 | | | |
| Northern Illinois | 31 | at | Toledo | 28 | | | |
| 11/14/2019 | Buffalo | 27 | at | Kent State | 30 | | | |
| 11/16/2019 | Central Michigan | 45 | at | Ball State | 44 | | | |
| 11/19/2019 | Ohio | 66 | at | Bowling Green | 24 | | | |
| Eastern Michigan | 45 | at | Northern Illinois | 17 | | | |
| 11/20/2019 | Toledo | 30 | at | Buffalo | 49 | | | |
| Akron | 17 | at | Miami-Ohio | 20 | | | |
| 11/23/2019 | Ball State | 38 | at | Kent State | 41 | | | |
| 11/26/2019 | Ohio | 52 | at | Akron | 3 | | | |
| Western Michigan | 14 | at | Northern Illinois | 17 | | | |
| 11/29/2019 | Miami-Ohio | 27 | at | Ball State | 41 | | | |
| Bowling Green | 7 | at | Buffalo | 49 | | | |
| Toledo | 7 | at | Central Michigan | 49 | | | |
| Kent State | 34 | at | Eastern Michigan | 26 | | | |
| 12/7/2019 | Miami-Ohio | 26 | vs | Central Michigan | 21 | | MAC Championship - Detroit MI | |
| 12/20/2019 | Utah State | 41 | vs | Kent State | 51 | | Frisco Bowl - Frisco TX | vs MW |
| Buffalo | 31 | vs | UNC-Charlotte | 9 | | Bahamas Bowl | vs CUSA |
| 12/21/2019 | Central Michigan | 11 | vs | San Diego State | 48 | | New Mexico Bowl - Albuquerque NM | vs MW |
| 12/26/2019 | Pittsburgh | 34 | vs | Eastern Michigan | 30 | | Quick Lane Bowl - Detroiut MI | vs ACC |
| 12/30/2019 | Western Kentucky | 23 | vs | Western Michigan | 20 | | First Responder Bowl - Dallas TX | vs CUSA |
| 1/3/2020 | Ohio | 30 | vs | Nevada | 21 | | Famous Idaho Potato Bowl - Boise ID | vs MW |
| 1/6/2020 | UL Lafayette | 27 | vs | Miami-Ohio | 17 | | Lendingtree Bowl - Mobile AL | vs SBC |