| 8/31/2019 | Miami-Ohio (8-6) | 14 | at | Iowa | 38 | MAC | ||
| 9/7/2019 | Rutgers (2-10,0-9) | 0 | at | Iowa | 30 | |||
| 9/14/2019 | Iowa | 18 | at | Iowa State (7-6) | 17 | at B12 | ||
| 9/28/2019 | Middle Tenn State (4-8) | 3 | at | Iowa | 48 | CUSA | ||
| 10/5/2019 | Iowa | 3 | at | Michigan (9-4,6-3) | 10 | |||
| 10/12/2019 | Penn State (11-2,7-2) | 17 | at | Iowa | 12 | |||
| 10/19/2019 | Purdue (4-8,3-6) | 20 | at | Iowa | 26 | |||
| 10/26/2019 | Iowa | 20 | at | Northwestern (3-9,1-8) | 0 | |||
| 11/9/2019 | Iowa | 22 | at | Wisconsin (10-4,7-3) | 24 | |||
| 11/16/2019 | Minnesota (11-2,7-2) | 19 | at | Iowa | 23 | |||
| 11/23/2019 | Illinois (6-7,4-5) | 10 | at | Iowa | 19 | |||
| 11/29/2019 | Iowa | 27 | at | Nebraska (5-7,3-6) | 24 | |||
| 12/27/2019 | Southern California (8-5) | 24 | vs | Iowa | 49 | Holiday Bowl - San Diego CA | P12 |
| vs Iowa | vs Other Opponents | Iowa compared to OOs | |
| Record: | 3-10 | 85-68 | |
| Points Scored: | 14.00 | 29.13 | 15.13 |
| Points Allowed: | 25.77 | 25.54 | 0.23 |
| Margin: | -11.77 | 3.59 | 15.36 |
| Total Points: | 39.77 | 54.67 | -14.90 |