| 8/29/2019 | Alabama State | 19 | at | UAB | 24 | | | SWAC (1AA) |
| Florida Intl | 14 | at | Tulane | 42 | | | @ AAC |
| Gardner-Webb | 28 | at | UNC-Charlotte | 49 | | | BigS (1AA) |
| Central Arkansas | 35 | at | Western Kentucky | 28 | | | SLC (1AA) |
| 8/30/2019 | Rice | 7 | at | Army | 14 | | | @ Ind |
| 8/31/2019 | VMI | 17 | at | Marshall | 56 | | | SoCon (1AA) |
| Middle Tenn State | 21 | at | Michigan | 40 | | | @ B10 |
| Abilene Christian | 31 | at | North Texas | 51 | | | SLC (1AA) |
| Florida Atlantic | 21 | at | Ohio State | 45 | | | @ B10 |
| Norfolk State | 21 | at | Old Dominion | 24 | | | MEAC (1AA) |
| Alcorn State | 10 | at | Southern Miss | 38 | | | SWAC (1AA) |
| Louisiana Tech | 14 | at | Texas | 45 | | | @ B12 |
| Incarnate Word | 7 | at | Texas-San Antonio | 35 | | | SLC (1AA) |
| Houston Baptist | 34 | at | UTEP | 36 | | | SLC (1AA) |
| 9/6/2019 | Marshall | 7 | at | Boise State | 14 | | | @ MW |
| Wake Forest | 41 | at | Rice | 21 | | | ACC |
| 9/7/2019 | UAB | 31 | at | Akron | 20 | | | @ MAC |
| UNC-Charlotte | 41 | at | Appalachian State | 56 | | | @ SBC |
| Texas-San Antonio | 14 | at | Baylor | 63 | | | @ B12 |
| UCF | 48 | at | Florida Atlantic | 14 | | | AAC |
| Western Kentucky | 20 | at | Florida Intl | 14 | | | |
| Grambling | 14 | at | Louisiana Tech | 20 | | | SWAC (1AA) |
| Tennessee State | 26 | at | Middle Tenn State | 45 | | | OVC (1AA) |
| Southern Miss | 15 | at | Mississippi State | 38 | | | @ SEC |
| North Texas | 27 | at | SMU | 49 | | | @ AAC |
| UTEP | 3 | at | Texas Tech | 38 | | | @ B12 |
| Old Dominion | 17 | at | Virginia Tech | 31 | | | @ ACC |
| 9/14/2019 | Florida Atlantic | 41 | at | Ball State | 31 | | | @ MAC |
| Louisiana Tech | 35 | at | Bowling Green | 7 | | | @ MAC |
| North Texas | 17 | at | California | 23 | | | @ P12 |
| New Hampshire | 17 | at | Florida Intl | 30 | | | CAAF (1AA) |
| Ohio | 31 | at | Marshall | 33 | | | MAC |
| Duke | 41 | at | Middle Tenn State | 18 | | | ACC |
| Texas | 48 | at | Rice | 13 | | | B12 |
| Army | 31 | at | Texas-San Antonio | 13 | | | Ind |
| Southern Miss | 47 | at | Troy | 42 | | | @ SBC |
| Massachusetts | 17 | at | UNC-Charlotte | 52 | | | Ind |
| Louisville | 38 | vs | Western Kentucky | 21 | | Nashville TN | vs ACC |
| 9/20/2019 | Florida Intl | 31 | at | Louisiana Tech | 43 | | | |
| 9/21/2019 | Southern Miss | 7 | at | Alabama | 49 | | | @ SEC |
| South Alabama | 3 | at | UAB | 35 | | | SBC |
| UNC-Charlotte | 10 | at | Clemson | 52 | | | @ ACC |
| Wagner | 7 | at | Florida Atlantic | 42 | | | NE (1AA) |
| Texas-San Antonio | 3 | at | North Texas | 45 | | | |
| Baylor | 21 | at | Rice | 13 | | | B12 |
| Nevada | 37 | at | UTEP | 21 | | | MW |
| Old Dominion | 17 | at | Virginia | 28 | | | @ ACC |
| 9/28/2019 | Middle Tenn State | 3 | at | Iowa | 48 | | | @ B10 |
| Cincinnati | 52 | at | Marshall | 14 | | | AAC |
| Houston | 46 | at | North Texas | 25 | | | AAC |
| East Carolina | 24 | at | Old Dominion | 21 | | | AAC |
| Louisiana Tech | 23 | at | Rice | 20 | OT | | |
| UTEP | 13 | at | Southern Miss | 31 | | | |
| Florida Atlantic | 45 | at | UNC-Charlotte | 27 | | | |
| UAB | 13 | at | Western Kentucky | 20 | | | |
| 10/5/2019 | Rice | 20 | at | UAB | 35 | | | |
| Massachusetts | 0 | at | Florida Intl | 44 | | | Ind |
| Marshall | 13 | at | Middle Tenn State | 24 | | | |
| Western Kentucky | 20 | at | Old Dominion | 3 | | | |
| Texas-San Antonio | 26 | at | UTEP | 16 | | | |
| 10/12/2019 | Middle Tenn State | 13 | at | Florida Atlantic | 28 | | | |
| UNC-Charlotte | 23 | at | Florida Intl | 48 | | | |
| Massachusetts | 21 | at | Louisiana Tech | 69 | | | Ind |
| Old Dominion | 17 | at | Marshall | 31 | | | |
| North Texas | 27 | at | Southern Miss | 45 | | | |
| UAB | 33 | at | Texas-San Antonio | 14 | | | |
| Army | 8 | at | Western Kentucky | 17 | | | Ind |
| 10/18/2019 | Marshall | 36 | at | Florida Atlantic | 31 | | | |
| 10/19/2019 | Old Dominion | 14 | at | UAB | 38 | | | |
| UTEP | 17 | at | Florida Intl | 32 | | | |
| Southern Miss | 30 | at | Louisiana Tech | 45 | | | |
| Middle Tenn State | 30 | at | North Texas | 33 | | | |
| Rice | 27 | at | Texas-San Antonio | 31 | | | |
| UNC-Charlotte | 14 | at | Western Kentucky | 30 | | | |
| 10/26/2019 | Western Kentucky | 23 | at | Marshall | 26 | | | |
| Florida Intl | 17 | at | Middle Tenn State | 50 | | | |
| Florida Atlantic | 41 | at | Old Dominion | 3 | | | |
| Southern Miss | 20 | at | Rice | 6 | | | |
| North Texas | 38 | at | UNC-Charlotte | 39 | | | |
| Louisiana Tech | 42 | at | UTEP | 21 | | | |
| 11/2/2019 | Old Dominion | 17 | at | Florida Intl | 24 | | | |
| UTEP | 26 | at | North Texas | 52 | | | |
| Marshall | 20 | at | Rice | 7 | | | |
| UAB | 7 | at | Tennessee | 30 | | | @ SEC |
| Texas-San Antonio | 14 | at | Texas A&M | 45 | | | @ SEC |
| Middle Tenn State | 20 | at | UNC-Charlotte | 34 | | | |
| Florida Atlantic | 35 | at | Western Kentucky | 24 | | | |
| 11/9/2019 | Western Kentucky | 45 | at | Arkansas | 19 | | | @ SEC |
| Florida Intl | 7 | at | Florida Atlantic | 37 | | | |
| North Texas | 17 | at | Louisiana Tech | 52 | | | |
| Texas-San Antonio | 24 | at | Old Dominion | 23 | | | |
| UAB | 2 | at | Southern Miss | 37 | | | |
| UNC-Charlotte | 28 | at | UTEP | 21 | | | |
| 11/15/2019 | Louisiana Tech | 10 | at | Marshall | 31 | | | |
| 11/16/2019 | UTEP | 10 | at | UAB | 37 | | | |
| Rice | 31 | at | Middle Tenn State | 28 | | | |
| Southern Miss | 36 | at | Texas-San Antonio | 17 | | | |
| 11/23/2019 | Louisiana Tech | 14 | at | UAB | 20 | | | |
| Miami-Florida | 24 | at | Florida Intl | 30 | | | ACC |
| Old Dominion | 17 | at | Middle Tenn State | 38 | | | |
| UTEP | 35 | at | New Mexico State | 44 | | | @ Ind |
| North Texas | 14 | at | Rice | 20 | | | |
| Western Kentucky | 28 | at | Southern Miss | 10 | | | |
| Florida Atlantic | 40 | at | Texas-San Antonio | 26 | | | |
| Marshall | 13 | at | UNC-Charlotte | 24 | | | |
| 11/30/2019 | Southern Miss | 17 | at | Florida Atlantic | 34 | | | |
| Texas-San Antonio | 27 | at | Louisiana Tech | 41 | | | |
| Florida Intl | 27 | at | Marshall | 30 | | | |
| UAB | 26 | at | North Texas | 21 | | | |
| UNC-Charlotte | 38 | at | Old Dominion | 22 | | | |
| Rice | 30 | at | UTEP | 16 | | | |
| Middle Tenn State | 26 | at | Western Kentucky | 31 | | | |
| 12/7/2019 | UAB | 6 | at | Florida Atlantic | 49 | | CUSA Championship | |
| 12/20/2019 | Buffalo | 31 | vs | UNC-Charlotte | 9 | | Bahamas Bowl | vs MAC |
| 12/21/2019 | Appalachian State | 31 | vs | UAB | 17 | | New Orleans Bowl - New Orleans LA | vs SBC |
| Florida Intl | 26 | vs | Arkansas State | 34 | | Camellia Bowl - Montgomery AL | vs SBC |
| SMU | 28 | vs | Florida Atlantic | 52 | | Boca Raton Bowl - Boca Raton FL | vs AAC |
| 12/23/2019 | UCF | 48 | vs | Marshall | 25 | | Gasparilla Bowl - Tampa FL | vs AAC |
| 12/26/2019 | Louisiana Tech | 14 | vs | Miami-Florida | 0 | | Independence Bowl - Shreveport LA | vs ACC |
| 12/30/2019 | Western Kentucky | 23 | vs | Western Michigan | 20 | | First Responder Bowl - Dallas TX | vs MAC |
| 1/4/2020 | Southern Miss | 13 | vs | Tulane | 30 | | Armed Forces Bowl - Fort Worth TX | vs AAC |