| 8/31/2019 | Duke | 3 | vs | Alabama (11-2) | 42 | Atlanta GA | vs SEC | |
| 9/7/2019 | North Carolina A&T (9-3) | 13 | at | Duke | 45 | MEAC (1AA) | ||
| 9/14/2019 | Duke | 41 | at | Middle Tenn State (4-8) | 18 | at CUSA | ||
| 9/27/2019 | Duke | 45 | at | Virginia Tech (8-5,5-3) | 10 | |||
| 10/5/2019 | Pittsburgh (8-5,4-4) | 33 | at | Duke | 30 | |||
| 10/12/2019 | Georgia Tech (3-9,2-6) | 23 | at | Duke | 41 | |||
| 10/19/2019 | Duke | 14 | at | Virginia (9-5,6-3) | 48 | |||
| 10/26/2019 | Duke | 17 | at | North Carolina (7-6,4-5) | 20 | |||
| 11/9/2019 | Notre Dame (11-2) | 38 | at | Duke | 7 | ND | ||
| 11/16/2019 | Syracuse (5-7,2-6) | 49 | at | Duke | 6 | |||
| 11/23/2019 | Duke | 27 | at | Wake Forest (8-5,5-4) | 39 | |||
| 11/30/2019 | Miami-Florida (6-7,4-4) | 17 | at | Duke | 27 |
| vs Duke | vs Other Opponents | Duke compared to OOs | |
| Record: | 7-5 | 82-59 | |
| Points Scored: | 29.17 | 30.90 | 1.73 |
| Points Allowed: | 25.25 | 24.67 | 0.58 |
| Margin: | 3.92 | 6.23 | 2.31 |
| Total Points: | 54.42 | 55.57 | -1.15 |