| 9/2/2019 | Notre Dame (11-2) | 35 | at | Louisville | 17 | ND | ||
| 9/7/2019 | Eastern Kentucky (7-5) | 0 | at | Louisville | 42 | OVC (1AA) | ||
| 9/14/2019 | Louisville | 38 | vs | Western Kentucky (9-4) | 21 | Nashville TN | vs CUSA | |
| 9/21/2019 | Louisville | 24 | at | Florida State (6-7,4-4) | 35 | |||
| 10/5/2019 | Boston College (6-7,4-4) | 39 | at | Louisville | 41 | |||
| 10/12/2019 | Louisville | 62 | at | Wake Forest (8-5,5-4) | 59 | |||
| 10/19/2019 | Clemson (14-1,9-0) | 45 | at | Louisville | 10 | |||
| 10/26/2019 | Virginia (9-5,6-3) | 21 | at | Louisville | 28 | |||
| 11/9/2019 | Louisville | 27 | at | Miami-Florida (6-7,4-4) | 52 | |||
| 11/16/2019 | Louisville | 34 | at | North Carolina State (4-8,1-7) | 20 | |||
| 11/23/2019 | Syracuse (5-7,2-6) | 34 | at | Louisville | 56 | |||
| 11/30/2019 | Louisville | 13 | at | Kentucky (8-5) | 45 | at SEC | ||
| 12/30/2019 | Mississippi State (6-7) | 28 | vs | Louisville | 38 | Music City Bowl - Nashville TN | SEC |
| vs Louisville | vs Other Opponents | Louisville compared to OOs | |
| Record: | 5-8 | 94-62 | |
| Points Scored: | 33.38 | 29.62 | -3.76 |
| Points Allowed: | 33.08 | 23.63 | 9.45 |
| Margin: | 0.30 | 5.99 | 5.69 |
| Total Points: | 66.46 | 53.25 | 13.21 |