| 9/1/2019 | Houston | 31 | at | Oklahoma (12-2) | 49 | at B12 | ||
| 9/7/2019 | Prairie View (6-5) | 17 | at | Houston | 37 | SWAC (1AA) | ||
| 9/13/2019 | Washington State (6-7) | 31 | at | Houston | 24 | P12 | ||
| 9/19/2019 | Houston | 31 | at | Tulane (7-6,3-5) | 38 | |||
| 9/28/2019 | Houston | 46 | at | North Texas (4-8) | 25 | at CUSA | ||
| 10/12/2019 | Cincinnati (11-3,7-2) | 38 | at | Houston | 23 | |||
| 10/19/2019 | Houston | 24 | at | Connecticut (2-10,0-8) | 17 | |||
| 10/24/2019 | SMU (10-3,6-2) | 34 | at | Houston | 31 | |||
| 11/2/2019 | Houston | 29 | at | UCF (10-3,6-2) | 44 | |||
| 11/16/2019 | Memphis (12-2,8-1) | 45 | at | Houston | 27 | |||
| 11/23/2019 | Houston | 24 | at | Tulsa (4-8,2-6) | 14 | |||
| 11/30/2019 | Navy (11-2,7-1) | 56 | at | Houston | 41 |
| vs Houston | vs Other Opponents | Houston compared to OOs | |
| Record: | 8-4 | 87-55 | |
| Points Scored: | 34.00 | 35.05 | 1.05 |
| Points Allowed: | 30.67 | 28.19 | 2.48 |
| Margin: | 3.33 | 6.86 | 3.53 |
| Total Points: | 64.67 | 63.24 | 1.43 |