| 8/30/2019 | Oklahoma State | 52 | at | Oregon State | 36 | @ P12 | ||
| 8/31/2019 | Stephen F. Austin | 17 | at | Baylor | 56 | SLC (1AA) | ||
| Northern Iowa | 26 | at | Iowa State | 29 | 3OT | MVC (1AA) | ||
| Indiana State | 17 | at | Kansas | 24 | MVC (1AA) | |||
| Nicholls State | 14 | at | Kansas State | 49 | SLC (1AA) | |||
| Ark Pine Bluff | 7 | at | TCU | 39 | SWAC (1AA) | |||
| Louisiana Tech | 14 | at | Texas | 45 | CUSA | |||
| Montana State | 10 | at | Texas Tech | 45 | BSky (1AA) | |||
| James Madison | 13 | at | West Virginia | 20 | CAAF (1AA) | |||
| 9/1/2019 | Houston | 31 | at | Oklahoma | 49 | AAC | ||
| 9/7/2019 | Texas-San Antonio | 14 | at | Baylor | 63 | CUSA | ||
| Coastal Carolina | 12 | at | Kansas | 7 | SBC | |||
| Bowling Green | 0 | at | Kansas State | 52 | MAC | |||
| West Virginia | 7 | at | Missouri | 38 | @ SEC | |||
| South Dakota | 14 | at | Oklahoma | 70 | MVC (1AA) | |||
| McNeese State | 14 | at | Oklahoma State | 56 | SLC (1AA) | |||
| LSU | 45 | at | Texas | 38 | SEC | |||
| UTEP | 3 | at | Texas Tech | 38 | CUSA | |||
| 9/13/2019 | Kansas | 48 | at | Boston College | 24 | @ ACC | ||
| 9/14/2019 | Texas Tech | 14 | at | Arizona | 28 | @ P12 | ||
| Iowa | 18 | at | Iowa State | 17 | B10 | |||
| Kansas State | 31 | at | Mississippi State | 24 | @ SEC | |||
| TCU | 34 | at | Purdue | 13 | @ B10 | |||
| Texas | 48 | at | Rice | 13 | @ CUSA | |||
| Oklahoma State | 40 | at | Tulsa | 21 | @ AAC | |||
| Oklahoma | 48 | at | UCLA | 14 | @ P12 | |||
| North Carolina State | 27 | at | West Virginia | 44 | ACC | |||
| 9/21/2019 | UL Monroe | 20 | at | Iowa State | 72 | SBC | ||
| West Virginia | 29 | at | Kansas | 24 | ||||
| Baylor | 21 | at | Rice | 13 | @ CUSA | |||
| SMU | 41 | at | TCU | 38 | AAC | |||
| Oklahoma State | 30 | at | Texas | 36 | ||||
| 9/28/2019 | Iowa State | 21 | at | Baylor | 23 | |||
| Texas Tech | 16 | at | Oklahoma | 55 | ||||
| Kansas State | 13 | at | Oklahoma State | 26 | ||||
| Kansas | 14 | at | TCU | 51 | ||||
| 10/5/2019 | TCU | 24 | at | Iowa State | 49 | |||
| Oklahoma | 45 | at | Kansas | 20 | ||||
| Baylor | 31 | at | Kansas State | 12 | ||||
| Oklahoma State | 35 | at | Texas Tech | 45 | ||||
| Texas | 42 | at | West Virginia | 31 | ||||
| 10/12/2019 | Texas Tech | 30 | at | Baylor | 33 | 2OT | ||
| Oklahoma | 34 | vs | Texas | 27 | Dallas TX | |||
| Iowa State | 38 | at | West Virginia | 14 | ||||
| 10/19/2019 | TCU | 17 | at | Kansas State | 24 | |||
| West Virginia | 14 | at | Oklahoma | 52 | ||||
| Baylor | 45 | at | Oklahoma State | 27 | ||||
| Kansas | 48 | at | Texas | 50 | ||||
| Iowa State | 34 | at | Texas Tech | 24 | ||||
| 10/26/2019 | Oklahoma State | 34 | at | Iowa State | 27 | |||
| Texas Tech | 34 | at | Kansas | 37 | ||||
| Oklahoma | 41 | at | Kansas State | 48 | ||||
| Texas | 27 | at | TCU | 37 | ||||
| 10/31/2019 | West Virginia | 14 | at | Baylor | 17 | |||
| 11/2/2019 | Kansas State | 38 | at | Kansas | 10 | |||
| TCU | 27 | at | Oklahoma State | 34 | ||||
| 11/9/2019 | Iowa State | 41 | at | Oklahoma | 42 | |||
| Baylor | 29 | at | TCU | 23 | 3OT | |||
| Kansas State | 24 | at | Texas | 27 | ||||
| Texas Tech | 38 | at | West Virginia | 17 | ||||
| 11/16/2019 | Oklahoma | 34 | at | Baylor | 31 | |||
| Texas | 21 | at | Iowa State | 23 | ||||
| West Virginia | 24 | at | Kansas State | 20 | ||||
| Kansas | 13 | at | Oklahoma State | 31 | ||||
| TCU | 33 | at | Texas Tech | 31 | ||||
| 11/23/2019 | Texas | 10 | at | Baylor | 24 | |||
| Kansas | 31 | at | Iowa State | 41 | ||||
| TCU | 24 | at | Oklahoma | 28 | ||||
| Kansas State | 30 | at | Texas Tech | 27 | ||||
| Oklahoma State | 20 | at | West Virginia | 13 | ||||
| 11/29/2019 | West Virginia | 20 | at | TCU | 17 | |||
| Texas Tech | 24 | at | Texas | 49 | ||||
| 11/30/2019 | Baylor | 61 | at | Kansas | 6 | |||
| Iowa State | 17 | at | Kansas State | 27 | ||||
| Oklahoma | 34 | at | Oklahoma State | 16 | ||||
| 12/7/2019 | Baylor | 23 | vs | Oklahoma | 30 | Big 12 Championship - Arlington TX | ||
| 12/27/2019 | Oklahoma State | 21 | vs | Texas A&M | 24 | Texas Bowl - Houston TX | vs SEC | |
| 12/28/2019 | Notre Dame | 33 | vs | Iowa State | 9 | Camping World Bowl - Orlando FL | vs ND | |
| Oklahoma | 28 | vs | LSU | 63 | 1A Semifinal - Peach Bowl - Atlanta GA | vs SEC | ||
| 12/31/2019 | Navy | 20 | vs | Kansas State | 17 | Liberty Bowl - Memphis TN | vs AAC | |
| Utah | 10 | vs | Texas | 38 | Alamo Bowl - San Antonio TX | vs P12 | ||
| 1/1/2020 | Georgia | 26 | vs | Baylor | 14 | Sugar Bowl - New Orleans LA | vs SEC |