| 9/1/2016 | Mars Hill (5-6) | 7 | at | Samford | 77 | SAC (D2) | ||
| 9/10/2016 | Samford | 35 | at | Central Arkansas (10-3) | 29 | at SLC | ||
| 9/24/2016 | Samford | 21 | at | Chattanooga (9-4,5-2) | 41 | |||
| 10/1/2016 | Wofford (10-4,6-2) | 26 | at | Samford | 28 | |||
| 10/8/2016 | Samford | 38 | at | Furman (3-8,2-5) | 21 | |||
| 10/15/2016 | VMI (3-8,0-7) | 21 | at | Samford | 55 | |||
| 10/22/2016 | Western Carolina (2-9,1-6) | 17 | at | Samford | 30 | |||
| 10/29/2016 | Samford | 41 | at | Mississippi State (6-7) | 56 | at SEC | ||
| 11/5/2016 | Samford | 34 | at | The Citadel (10-2,7-1) | 37 | OT | ||
| 11/12/2016 | Mercer (6-5,3-4) | 19 | at | Samford | 24 | |||
| 11/19/2016 | Samford | 14 | at | East Tennessee St (5-6) | 15 | at IndFCS | ||
| 11/26/2016 | Samford | 24 | at | Youngstown State (12-4) | 38 | at MVC |
| vs Samford | vs Other Opponents | Samford compared to OOs | |
| Record: | 5-7 | 76-59 | |
| Points Scored: | 27.25 | 27.10 | -0.15 |
| Points Allowed: | 35.08 | 24.79 | 10.29 |
| Margin: | -7.83 | 2.31 | 10.14 |
| Total Points: | 62.33 | 51.89 | 10.44 |