| 9/1/2016 | UNC-Charlotte (4-8) | 14 | at | Louisville | 70 | CUSA | ||
| 9/9/2016 | Louisville | 62 | at | Syracuse (4-8,2-6) | 28 | |||
| 9/17/2016 | Florida State (10-3,5-3) | 20 | at | Louisville | 63 | |||
| 9/24/2016 | Louisville | 59 | at | Marshall (3-9) | 28 | at CUSA | ||
| 10/1/2016 | Louisville | 36 | at | Clemson (14-1,8-1) | 42 | |||
| 10/14/2016 | Duke (4-8,1-7) | 14 | at | Louisville | 24 | |||
| 10/22/2016 | North Carolina State (7-6,3-5) | 13 | at | Louisville | 54 | |||
| 10/29/2016 | Louisville | 32 | at | Virginia (2-10,1-7) | 25 | |||
| 11/5/2016 | Louisville | 52 | at | Boston College (7-6,2-6) | 7 | |||
| 11/12/2016 | Wake Forest (7-6,3-5) | 12 | at | Louisville | 44 | |||
| 11/17/2016 | Louisville | 10 | at | Houston (9-4) | 36 | at AAC | ||
| 11/26/2016 | Kentucky (7-6) | 41 | at | Louisville | 38 | SEC | ||
| 12/31/2016 | LSU (8-4) | 29 | vs | Louisville | 9 | Citrus Bowl (Orlando FL) | SEC |
| vs Louisville | vs Other Opponents | Louisville compared to OOs | |
| Record: | 4-9 | 82-70 | |
| Points Scored: | 23.77 | 28.22 | 4.45 |
| Points Allowed: | 42.54 | 25.63 | 16.91 |
| Margin: | -18.77 | 2.59 | 21.36 |
| Total Points: | 66.31 | 53.85 | 12.46 |