| 9/1/2016 | Kentucky Wesleyan | 29 | at | Delta State | 50 | @ GSC | ||
| West Alabama | 23 | at | North Greenville | 24 | GSC | |||
| Alderson-Broaddus | 14 | at | Robert Morris | 7 | @ NE (1AA) | |||
| 9/3/2016 | Limestone | 35 | at | Shaw | 6 | @ CIAA | ||
| UNC Pembroke | 20 | at | Winston-Salem State | 17 | @ CIAA | |||
| 9/10/2016 | Limestone | 19 | at | Benedict | 13 | @ SIAC | ||
| Davidson | 35 | at | Kentucky Wesleyan | 21 | Pio (1AA) | |||
| North Greenville | 45 | at | Lenoir-Rhyne | 0 | @ SAC | |||
| Alderson-Broaddus | 6 | at | St Joseph's | 13 | @ GLV | |||
| Fayetteville State | 28 | at | UNC Pembroke | 50 | CIAA | |||
| 9/17/2016 | Kentucky Wesleyan | 7 | at | Davenport | 41 | @ NAIAInd (NAIA) | ||
| Mars Hill | 42 | at | Limestone | 39 | SAC | |||
| Newberry | 29 | at | North Greenville | 28 | SAC | |||
| UNC Pembroke | 38 | at | Shaw | 19 | @ CIAA | |||
| 9/22/2016 | Fairmont State | 16 | at | Alderson-Broaddus | 3 | MtnE | ||
| 9/24/2016 | Indianapolis | 37 | at | Kentucky Wesleyan | 7 | GLV | ||
| Limestone | 31 | at | Lenoir-Rhyne | 13 | @ SAC | |||
| North Greenville | 35 | at | UNC Pembroke | 49 | ||||
| 10/1/2016 | Fort Valley State | 9 | at | Alderson-Broaddus | 33 | SIAC | ||
| Central State | 7 | at | Kentucky Wesleyan | 21 | SIAC | |||
| Wingate | 45 | at | Limestone | 26 | SAC | |||
| Mars Hill | 21 | at | North Greenville | 56 | SAC | |||
| UNC Pembroke | 16 | at | Tuskegee | 21 | @ SIAC | |||
| 10/6/2016 | North Greenville | 14 | at | The Citadel | 38 | @ SoCon (1AA) | ||
| 10/8/2016 | Limestone | 6 | at | Catawba | 0 | @ SAC | ||
| UNC Pembroke | 36 | at | Lenoir-Rhyne | 20 | @ SAC | |||
| Alderson-Broaddus | 35 | at | Malone | 16 | @ GLIAC | |||
| Kentucky Wesleyan | 7 | at | Northwestern State | 49 | @ SLC (1AA) | |||
| 10/13/2016 | Alderson-Broaddus | 19 | at | Glenville State | 7 | @ MtnE | ||
| 10/15/2016 | Brevard | 17 | at | Limestone | 28 | SAC | ||
| North Greenville | 31 | at | Tusculum | 7 | @ SAC | |||
| Kentucky Wesleyan | 20 | at | UNC Pembroke | 43 | ||||
| 10/22/2016 | Alderson-Broaddus | 38 | at | Georgetown KY | 13 | @ MSC (NAIA) | ||
| Ashland | 70 | at | Kentucky Wesleyan | 14 | GLIAC | |||
| North Greenville | 21 | at | North Alabama | 52 | @ GSC | |||
| Limestone | 13 | at | Tusculum | 34 | @ SAC | |||
| Catawba | 31 | at | UNC Pembroke | 41 | SAC | |||
| 10/29/2016 | Kentucky Wesleyan | 52 | at | Alfred State | 7 | @ D3Ind (D3) | ||
| Limestone | 25 | at | Carson-Newman | 39 | @ SAC | |||
| Wingate | 30 | at | North Greenville | 34 | SAC | |||
| UNC Pembroke | 44 | at | West Virginia State | 14 | @ MtnE | |||
| 11/5/2016 | Charleston WV | 17 | at | Alderson-Broaddus | 34 | MtnE | ||
| Malone | 30 | at | Kentucky Wesleyan | 40 | GLIAC | |||
| Newberry | 49 | at | Limestone | 7 | SAC | |||
| Carson-Newman | 24 | at | North Greenville | 34 | SAC | |||
| 11/12/2016 | Kentucky Wesleyan | 28 | at | Alderson-Broaddus | 31 | |||
| North Greenville | 37 | at | Limestone | 0 | ||||
| Concord | 18 | at | UNC Pembroke | 19 | MtnE | |||
| 11/19/2016 | North Greenville | 27 | at | Florida Tech | 13 | @ GSC | ||
| UNC Pembroke | 24 | at | Valdosta State | 21 | @ GSC | |||
| 11/26/2016 | UNC Pembroke | 17 | at | North Alabama | 41 | @ GSC | ||
| Tuskegee | 26 | at | North Greenville | 45 | SIAC | |||
| 12/3/2016 | North Greenville | 0 | at | North Alabama | 38 | D2 Quarterfinal | @ GSC |