| 9/3/2016 | Tuskegee | 36 | at | Clark Atlanta (5-5,3-4) | 13 | |||
| 9/10/2016 | Tuskegee | 28 | vs | Albany State GA (5-4,4-2) | 18 | Phenix City AL | ||
| 9/17/2016 | Florida A&M (4-7) | 17 | vs | Tuskegee | 20 | Mobile AL | MEAC (1AA) | |
| 9/24/2016 | Lane (5-5,3-4) | 7 | at | Tuskegee | 38 | |||
| 10/1/2016 | UNC Pembroke (10-2) | 16 | at | Tuskegee | 21 | D2Ind | ||
| 10/8/2016 | Tuskegee | 28 | vs | Morehouse (3-7,2-6) | 19 | Columbus GA | ||
| 10/22/2016 | Kentucky State (4-7,4-4) | 10 | at | Tuskegee | 9 | |||
| 10/29/2016 | Tuskegee | 42 | at | Central State (1-9,1-6) | 14 | |||
| 11/5/2016 | Tuskegee | 13 | at | Miles (5-5,5-3) | 10 | |||
| 11/12/2016 | Virginia State (9-2) | 45 | at | Tuskegee | 35 | CIAA | ||
| 11/19/2016 | Tuskegee | 35 | at | Newberry (10-2) | 33 | at SAC | ||
| 11/26/2016 | Tuskegee | 26 | at | North Greenville (9-5) | 45 | at D2Ind |
| vs Tuskegee | vs Other Opponents | Tuskegee compared to OOs | |
| Record: | 3-9 | 67-51 | |
| Points Scored: | 20.58 | 26.15 | 5.57 |
| Points Allowed: | 27.58 | 24.11 | 3.47 |
| Margin: | -7.00 | 2.04 | 9.04 |
| Total Points: | 48.16 | 50.26 | -2.10 |