| 9/1/2016 | Virginia-Wise (6-5) | 13 | at | Tusculum | 10 | 2OT | MtnE | |
| 9/10/2016 | Tusculum | 10 | at | Virginia State (9-2) | 24 | at CIAA | ||
| 9/17/2016 | Tusculum | 3 | at | Lenoir-Rhyne (3-8,3-4) | 31 | |||
| 9/24/2016 | Newberry (10-2,7-0) | 37 | at | Tusculum | 10 | |||
| 10/1/2016 | Brevard (1-10,0-7) | 14 | at | Tusculum | 21 | |||
| 10/8/2016 | Tusculum | 0 | at | Wingate (8-3,5-2) | 19 | |||
| 10/15/2016 | North Greenville (9-5) | 31 | at | Tusculum | 7 | D2Ind | ||
| 10/22/2016 | Limestone (5-6) | 13 | at | Tusculum | 34 | D2Ind | ||
| 10/29/2016 | Tusculum | 27 | at | Mars Hill (5-6,3-4) | 28 | OT | ||
| 11/5/2016 | Tusculum | 38 | at | Catawba (5-6,5-2) | 28 | |||
| 11/12/2016 | Carson-Newman (4-7,2-5) | 30 | at | Tusculum | 31 | OT |
| vs Tusculum | vs Other Opponents | Tusculum compared to OOs | |
| Record: | 7-4 | 58-56 | |
| Points Scored: | 24.36 | 27.39 | 3.03 |
| Points Allowed: | 17.36 | 27.64 | -10.28 |
| Margin: | 7.00 | -0.25 | -7.25 |
| Total Points: | 41.72 | 55.03 | -13.31 |