| 9/3/2016 | UNC Pembroke (10-2) | 20 | at | Winston-Salem State | 17 | D2Ind | ||
| 9/10/2016 | Winston-Salem State | 23 | at | Catawba (5-6) | 17 | at SAC | ||
| 9/17/2016 | Virginia Union (5-5,5-3) | 37 | at | Winston-Salem State | 14 | |||
| 9/24/2016 | Virginia State (9-2,5-2) | 14 | at | Winston-Salem State | 35 | |||
| 10/1/2016 | Winston-Salem State | 51 | at | Lincoln PA (1-9,0-7) | 10 | |||
| 10/9/2016 | Winston-Salem State | 15 | at | Johnson C Smith (3-7,3-5) | 14 | |||
| 10/15/2016 | St Augustine's (2-8,2-5) | 10 | at | Winston-Salem State | 45 | |||
| 10/22/2016 | Livingstone (2-8,1-6) | 21 | at | Winston-Salem State | 40 | |||
| 10/29/2016 | Winston-Salem State | 30 | at | Shaw (2-8,2-5) | 23 | |||
| 11/5/2016 | Winston-Salem State | 28 | at | Fayetteville State (4-6,4-4) | 21 | |||
| 11/12/2016 | Winston-Salem State | 43 | vs | Bowie State (7-4,7-2) | 33 | "Salem, VA" | ||
| 11/19/2016 | Winston-Salem State | 41 | at | LIU Post (12-1) | 48 | at NE10 |
| vs Winston-Salem State | vs Other Opponents | Winston-Salem State compared to OOs | |
| Record: | 3-9 | 59-57 | |
| Points Scored: | 22.33 | 26.80 | 4.47 |
| Points Allowed: | 31.83 | 28.22 | 3.61 |
| Margin: | -9.50 | -1.42 | 8.08 |
| Total Points: | 54.16 | 55.02 | -0.86 |