| 9/3/2016 | Central State | 19 | at | Dayton (9-2) | 31 | at Pio | ||
| 9/10/2016 | Clark Atlanta (5-5,3-4) | 20 | vs | Central State | 13 | Chicago IL | ||
| 9/17/2016 | Benedict (5-6,4-3) | 42 | at | Central State | 6 | |||
| 9/24/2016 | Kentucky State (4-7,4-4) | 17 | vs | Central State | 14 | Indianapolis IN | ||
| 10/1/2016 | Central State | 7 | at | Kentucky Wesleyan (3-8) | 21 | at D2Ind | ||
| 10/8/2016 | Central State | 0 | at | Miles (5-5,5-3) | 36 | |||
| 10/15/2016 | Lane (5-5,3-4) | 10 | at | Central State | 27 | |||
| 10/22/2016 | Central State | 28 | at | Fort Valley State (5-6,5-4) | 30 | |||
| 10/29/2016 | Tuskegee (9-3,6-1) | 42 | at | Central State | 14 | |||
| 11/5/2016 | Southwest Baptist (10-2) | 54 | at | Central State | 34 | GLV |
| vs Central State | vs Other Opponents | Central State compared to OOs | |
| Record: | 9-1 | 51-48 | |
| Points Scored: | 30.30 | 24.38 | -5.92 |
| Points Allowed: | 16.20 | 26.35 | -10.15 |
| Margin: | 14.10 | -1.97 | -16.07 |
| Total Points: | 46.50 | 50.73 | -4.23 |