| 9/3/2016 | Indianapolis | 24 | at | Hillsdale (5-5) | 30 | at GLIAC | ||
| 9/10/2016 | Marian IN (11-1) | 38 | at | Indianapolis | 16 | MSFA (NAIA) | ||
| 9/17/2016 | Indianapolis | 37 | at | Southwest Baptist (10-2,7-1) | 41 | |||
| 9/24/2016 | Indianapolis | 37 | at | Kentucky Wesleyan (3-8) | 7 | at D2Ind | ||
| 10/1/2016 | Indianapolis | 17 | at | Truman State (8-3,7-1) | 24 | |||
| 10/8/2016 | McKendree (8-3,6-2) | 24 | at | Indianapolis | 34 | |||
| 10/15/2016 | Indianapolis | 20 | at | Quincy (5-6,3-5) | 33 | |||
| 10/22/2016 | Lincoln MO (1-10,0-8) | 7 | at | Indianapolis | 38 | |||
| 10/29/2016 | William Jewell (1-9,1-7) | 12 | at | Indianapolis | 34 | |||
| 11/5/2016 | Indianapolis | 16 | at | Missouri S&T (5-6,4-4) | 6 | |||
| 11/12/2016 | St Joseph's (5-6,3-5) | 16 | at | Indianapolis | 21 |
| vs Indianapolis | vs Other Opponents | Indianapolis compared to OOs | |
| Record: | 5-6 | 57-53 | |
| Points Scored: | 21.64 | 29.69 | 8.05 |
| Points Allowed: | 26.73 | 27.15 | -0.42 |
| Margin: | -5.09 | 2.54 | 7.63 |
| Total Points: | 48.37 | 56.84 | -8.47 |