| 8/28/2010 | Iowa Wesleyan Tigers 6 @ Trinity International 16 | † |
| 9/4/2010 | Saint Ambrose Bees 17 @ Trinity International 9 | † |
| 9/11/2010 | Trinity International 6 @ St Xavier Cougars 62 | † |
| 9/18/2010 | Trinity International 23 @ Waldorf Warriors 21 | † |
| 9/25/2010 | William Penn Statesmen 44 @ Trinity International 0 | † |
| 10/2/2010 | Trinity International 0 @ Marian IN Knights 28 | † |
| 10/9/2010 | Trinity International 41 @ Olivet Nazarene Tigers 40 | † |
| 10/16/2010 | St Francis IN Fighting Saints 33 @ Trinity International 6 | † |
| 10/23/2010 | Taylor Trojans 25 @ Trinity International 10 | † |
| 10/30/2010 | Malone Pioneers 34 @ Trinity International 0 | † |
| 11/6/2010 | Trinity International 17 @ Walsh Cavaliers 42 | † |