| 8/28/2010 | Olivet Nazarene 9 @ West Virginia Tech Golden Bears 31 | |
| 9/4/2010 | Olivet Nazarene 0 @ McKendree Bearcats 41 | † |
| 9/11/2010 | Olivet Nazarene 7 @ Coe Kohawks 45 | |
| 9/18/2010 | St Xavier Cougars 58 @ Olivet Nazarene 17 | † |
| 10/2/2010 | Walsh Cavaliers 45 @ Olivet Nazarene 14 | † |
| 10/9/2010 | Trinity International Trojans 41 @ Olivet Nazarene 40 | † |
| 10/16/2010 | Olivet Nazarene 16 @ Marian IN Knights 42 | † |
| 10/23/2010 | St Francis IL Fighting Saints 49 @ Olivet Nazarene 35 | † |
| 10/30/2010 | St Francis IN Fighting Saints 63 @ Olivet Nazarene 7 | † |
| 11/6/2010 | Olivet Nazarene 13 @ Taylor Trojans 40 | † |
| 11/13/2010 | Olivet Nazarene 21 @ Malone Pioneers 56 | † |