| 8/26/2010 | St Xavier 49 @ Bethel TN Wildcats 32 | |
| 9/4/2010 | St Francis IL Fighting Saints 21 @ St Xavier 52 | † |
| 9/11/2010 | Trinity International Trojans 6 @ St Xavier 62 | † |
| 9/18/2010 | St Xavier 58 @ Olivet Nazarene Tigers 17 | † |
| 9/25/2010 | St Xavier 45 @ Quincy Hawks 14 | † |
| 10/2/2010 | Taylor Trojans 21 @ St Xavier 46 | † |
| 10/9/2010 | Marian IN Knights 25 @ St Xavier 56 | † |
| 10/16/2010 | St Xavier 55 @ Malone Pioneers 16 | † |
| 10/23/2010 | St Xavier 65 @ Iowa Wesleyan Tigers 6 | † |
| 10/30/2010 | Walsh Cavaliers 10 @ St Xavier 41 | † |
| 11/6/2010 | St Francis IN Fighting Saints 6 @ St Xavier 30 | † |
| 11/20/2010 | Cumberlands KY Patriots 19 @ St Xavier 66 | |
| 11/27/2010 | St Francis IN Fighting Saints 21 @ St Xavier 40 | † |
| 12/4/2010 | St Xavier 5 @ Carroll MT Saints 27 |