| 8/28/2010 | St Francis IL 17 @ Marian IN Knights 37 | † |
| 9/4/2010 | St Francis IL 21 @ St Xavier Cougars 52 | † |
| 9/11/2010 | Grand View Vikings 10 @ St Francis IL 17 | † |
| 9/25/2010 | Iowa Wesleyan Tigers 24 @ St Francis IL 21 | † |
| 10/2/2010 | St Francis IL 27 @ Saint Ambrose Bees 24 | † |
| 10/9/2010 | McKendree Bearcats 24 @ St Francis IL 28 | † |
| 10/16/2010 | Haskell Indians 16 @ St Francis IL 61 | |
| 10/23/2010 | St Francis IL 49 @ Olivet Nazarene Tigers 35 | † |
| 10/30/2010 | Waldorf Warriors 10 @ St Francis IL 56 | † |
| 11/6/2010 | Quincy Hawks 3 @ St Francis IL 35 | † |
| 11/13/2010 | St Francis IL 7 @ William Penn Statesmen 24 | † |