| 8/28/2010 | Iowa Wesleyan 6 @ Trinity International Trojans 16 | † |
| 9/4/2010 | Coe Kohawks 48 @ Iowa Wesleyan 21 | |
| 9/11/2010 | St Francis IN Fighting Saints 28 @ Iowa Wesleyan 7 | † |
| 9/18/2010 | Iowa Wesleyan 3 @ McKendree Bearcats 58 | † |
| 9/25/2010 | Iowa Wesleyan 24 @ St Francis IL Fighting Saints 21 | † |
| 10/2/2010 | Waldorf Warriors 24 @ Iowa Wesleyan 30 | † |
| 10/9/2010 | William Penn Statesmen 56 @ Iowa Wesleyan 41 | † |
| 10/16/2010 | Iowa Wesleyan 62 @ Quincy Hawks 50 | † |
| 10/23/2010 | St Xavier Cougars 65 @ Iowa Wesleyan 6 | † |
| 10/30/2010 | Iowa Wesleyan 6 @ Grand View Vikings 73 | † |
| 11/13/2010 | Saint Ambrose Bees 49 @ Iowa Wesleyan 10 | † |