| 9/4/2010 | Coe 48 @ Iowa Wesleyan Tigers 21 | |
| 9/11/2010 | Olivet Nazarene Tigers 7 @ Coe 45 | |
| 9/18/2010 | Coe 42 @ Luther Norse 19 | † |
| 9/25/2010 | Central IA Dutch 28 @ Coe 37 | † |
| 10/2/2010 | Coe 24 @ Dubuque Spartans 22 | † |
| 10/16/2010 | Wartburg Knights 31 @ Coe 21 | † |
| 10/23/2010 | Coe 42 @ Simpson Storm 21 | † |
| 10/30/2010 | Loras Duhawks 6 @ Coe 34 | † |
| 11/6/2010 | Buena Vista Beavers 14 @ Coe 44 | † |
| 11/13/2010 | Coe 47 @ Cornell IA Rams 7 | † |
| 11/20/2010 | Coe 21 @ Wheaton Thunder 31 (D3 Playoffs Round 1) |