| 8/28/2010 | Cumberlands KY Patriots 27 vs McKendree 34 (Dyersburg TN) | |
| 9/4/2010 | Olivet Nazarene Tigers 0 @ McKendree 41 | † |
| 9/11/2010 | McKendree 12 @ Marian IN Knights 45 | † |
| 9/18/2010 | Iowa Wesleyan Tigers 3 @ McKendree 58 | † |
| 9/25/2010 | McKendree 21 @ Saint Ambrose Bees 14 | † |
| 10/9/2010 | McKendree 24 @ St Francis IL Fighting Saints 28 | † |
| 10/16/2010 | McKendree 54 @ Waldorf Warriors 7 | † |
| 10/23/2010 | William Penn Statesmen 14 @ McKendree 24 | † |
| 10/30/2010 | McKendree 50 @ Quincy Hawks 21 | † |
| 11/13/2010 | Grand View Vikings 17 @ McKendree 20 | † |
| 11/20/2010 | McKendree 38 @ McPherson Bulldogs 14 | |
| 11/27/2010 | McKendree 7 @ Sioux Falls Cougars 27 |