| 9/4/2010 | Catholic 16 @ Shenandoah Hornets 13 | |
| 9/11/2010 | Apprentice Ship Builders 32 @ Catholic 42 | |
| 9/18/2010 | McDaniel Green Terror 24 @ Catholic 14 | |
| 9/25/2010 | Catholic 31 @ Albright Lions 41 | |
| 10/2/2010 | Hampden-Sydney Tigers 35 @ Catholic 27 | † |
| 10/9/2010 | Catholic 28 @ Randolph-Macon Yellow Jackets 56 | † |
| 10/23/2010 | Catholic 33 @ Emory & Henry Wasps 31 | † |
| 10/29/2010 | Washington and Lee Generals 49 @ Catholic 14 | † |
| 11/6/2010 | Catholic 23 @ Guilford Quakers 22 | † |
| 11/13/2010 | Bridgewater VA Eagles 38 @ Catholic 28 | † |