| 9/4/2010 | Widener 0 @ Alfred Saxons 37 | |
| 9/11/2010 | Thiel Tomcats 0 @ Widener 21 | |
| 9/18/2010 | Ithaca Bombers 31 @ Widener 7 | |
| 10/2/2010 | Fairleigh Dickinson-Florham Devils 20 @ Widener 35 | † |
| 10/9/2010 | Widener 36 @ King's Monarchs 21 | † |
| 10/16/2010 | Widener 7 @ Lycoming Warriors 31 | † |
| 10/23/2010 | Albright Lions 35 @ Widener 27 | † |
| 10/30/2010 | Widener 38 @ Lebanon Valley Flying Dutchmen 42 | † |
| 11/6/2010 | Wilkes Colonels 21 @ Widener 41 | † |
| 11/13/2010 | Widener 28 @ Delaware Valley Aggies 27 | † |