| 9/4/2010 | Allegheny 28 @ Bethany WV Bison 0 | |
| 9/11/2010 | Carnegie Mellon Tartans 27 @ Allegheny 34 | |
| 9/25/2010 | Wittenberg Tigers 24 @ Allegheny 21 | † |
| 10/2/2010 | Allegheny 23 @ Case Western Reserve Spartans 24 | |
| 10/9/2010 | Kenyon Lords 0 @ Allegheny 24 | † |
| 10/16/2010 | Allegheny 17 @ Denison Big Red 16 | † |
| 10/23/2010 | Ohio Wesleyan Battling Bishops 21 @ Allegheny 41 | † |
| 10/30/2010 | Allegheny 3 @ Wabash Little Giants 20 | † |
| 11/6/2010 | Allegheny 43 @ Hiram Terriers 21 | † |
| 11/13/2010 | Allegheny 17 @ Oberlin Yeomen 14 | † |