| 9/4/2010 | Ohio Wesleyan 6 @ Denison Big Red 21 | † |
| 9/11/2010 | Ohio Wesleyan 0 @ Wittenberg Tigers 52 | † |
| 9/18/2010 | Wabash Little Giants 45 @ Ohio Wesleyan 21 | † |
| 9/25/2010 | Wooster Scots 22 @ Ohio Wesleyan 13 | † |
| 10/2/2010 | Ohio Wesleyan 6 @ Chicago Maroons 30 | |
| 10/9/2010 | Carnegie Mellon Tartans 35 @ Ohio Wesleyan 23 | |
| 10/23/2010 | Ohio Wesleyan 21 @ Allegheny Gators 41 | † |
| 10/30/2010 | Kenyon Lords 14 @ Ohio Wesleyan 30 | † |
| 11/6/2010 | Ohio Wesleyan 12 @ Oberlin Yeomen 16 | † |
| 11/13/2010 | Hiram Terriers 24 @ Ohio Wesleyan 47 | † |