| 9/4/2010 | Ohio Wesleyan Battling Bishops 6 @ Denison 21 | † |
| 9/11/2010 | Earlham Hustlin' Quakers 20 @ Denison 41 | |
| 9/18/2010 | Denison 31 @ Hiram Terriers 24 1OT | † |
| 9/25/2010 | Denison 7 @ Case Western Reserve Spartans 37 | |
| 10/2/2010 | Wooster Scots 38 @ Denison 28 | † |
| 10/9/2010 | Denison 7 @ Chicago Maroons 36 | |
| 10/16/2010 | Allegheny Gators 17 @ Denison 16 | † |
| 10/23/2010 | Wabash Little Giants 55 @ Denison 20 | † |
| 10/30/2010 | Denison 10 @ Oberlin Yeomen 20 | † |
| 11/13/2010 | Denison 27 @ Kenyon Lords 7 | † |