| 9/2/2010 | Wooster 14 @ Baldwin-Wallace Yellow Jackets 38 | |
| 9/11/2010 | Wooster 17 @ Wabash Little Giants 21 | † |
| 9/18/2010 | Oberlin Yeomen 14 @ Wooster 31 | † |
| 9/25/2010 | Wooster 22 @ Ohio Wesleyan Battling Bishops 13 | † |
| 10/2/2010 | Wooster 38 @ Denison Big Red 28 | † |
| 10/16/2010 | Washington U Bears 14 @ Wooster 13 | |
| 10/23/2010 | Wooster 14 @ Case Western Reserve Spartans 28 | |
| 10/30/2010 | Hiram Terriers 0 @ Wooster 62 | † |
| 11/6/2010 | Kenyon Lords 6 @ Wooster 31 | † |
| 11/13/2010 | Wittenberg Tigers 22 @ Wooster 17 | † |