| 9/4/2010 | Chicago 28 @ Beloit Buccaneers 25 | |
| 9/11/2010 | Concordia IL Cougars 24 @ Chicago 56 | |
| 9/18/2010 | Chicago 20 @ Elmhurst Bluejays 31 | |
| 9/25/2010 | Chicago 14 @ Wabash Little Giants 31 | |
| 10/2/2010 | Ohio Wesleyan Battling Bishops 6 @ Chicago 30 | |
| 10/9/2010 | Denison Big Red 7 @ Chicago 36 | |
| 10/23/2010 | Chicago 35 @ Kenyon Lords 14 | |
| 10/30/2010 | Case Western Reserve Spartans 20 @ Chicago 24 | † |
| 11/6/2010 | Chicago 61 @ Carnegie Mellon Tartans 22 | † |
| 11/13/2010 | Washington U Bears 10 @ Chicago 13 | † |