| 9/4/2010 | Westminster PA Titans 23 @ Hiram 6 | |
| 9/11/2010 | Hiram 21 @ Kenyon Lords 13 | † |
| 9/18/2010 | Denison Big Red 31 @ Hiram 24 1OT | † |
| 9/25/2010 | Oberlin Yeomen 47 @ Hiram 21 | † |
| 10/2/2010 | Hiram 31 @ Carnegie Mellon Tartans 62 | |
| 10/9/2010 | Hiram 7 @ Wittenberg Tigers 49 | † |
| 10/16/2010 | Case Western Reserve Spartans 41 @ Hiram 0 | |
| 10/30/2010 | Hiram 0 @ Wooster Scots 62 | † |
| 11/6/2010 | Allegheny Gators 43 @ Hiram 21 | † |
| 11/13/2010 | Hiram 24 @ Ohio Wesleyan Battling Bishops 47 | † |