| 9/4/2010 | Oberlin 29 @ Kenyon Lords 26 1OT | † |
| 9/18/2010 | Oberlin 14 @ Wooster Scots 31 | † |
| 9/25/2010 | Oberlin 47 @ Hiram Terriers 21 | † |
| 10/2/2010 | Wittenberg Tigers 27 @ Oberlin 21 | † |
| 10/9/2010 | Case Western Reserve Spartans 48 @ Oberlin 36 | |
| 10/16/2010 | Oberlin 21 @ Wabash Little Giants 42 | † |
| 10/23/2010 | Oberlin 7 @ Washington U Bears 21 | |
| 10/30/2010 | Denison Big Red 10 @ Oberlin 20 | † |
| 11/6/2010 | Ohio Wesleyan Battling Bishops 12 @ Oberlin 16 | † |
| 11/13/2010 | Allegheny Gators 17 @ Oberlin 14 | † |