| 9/4/2010 | Olivet Comets 6 @ Wittenberg 48 | |
| 9/11/2010 | Ohio Wesleyan Battling Bishops 0 @ Wittenberg 52 | † |
| 9/18/2010 | Washington U Bears 7 @ Wittenberg 37 | |
| 9/25/2010 | Wittenberg 24 @ Allegheny Gators 21 | † |
| 10/2/2010 | Wittenberg 27 @ Oberlin Yeomen 21 | † |
| 10/9/2010 | Hiram Terriers 7 @ Wittenberg 49 | † |
| 10/16/2010 | Kenyon Lords 0 @ Wittenberg 52 | † |
| 10/23/2010 | Wittenberg 27 @ Carnegie Mellon Tartans 21 1OT | |
| 11/6/2010 | Wabash Little Giants 17 @ Wittenberg 34 | † |
| 11/13/2010 | Wittenberg 22 @ Wooster Scots 17 | † |
| 11/20/2010 | Wittenberg 14 @ Ohio Northern Polar Bears 37 (D3 Playoffs Round 1) |