| 9/4/2010 | Sewanee Tigers 33 @ Earlham 14 | |
| 9/11/2010 | Earlham 20 @ Denison Big Red 41 | |
| 9/18/2010 | Earlham 7 @ Manchester Spartans 28 | † |
| 9/25/2010 | Anderson Ravens 56 @ Earlham 20 | † |
| 10/2/2010 | Bluffton Beavers 26 @ Earlham 7 | † |
| 10/9/2010 | Earlham 23 @ Hanover Panthers 51 | † |
| 10/16/2010 | Defiance Yellow Jackets 33 @ Earlham 0 | † |
| 10/23/2010 | Mt St Joseph Lions 54 @ Earlham 6 | † |
| 11/6/2010 | Earlham 0 @ Franklin Grizzlies 60 | † |
| 11/13/2010 | Earlham 15 @ Rose-Hulman Engineers 40 | † |